In heart disease prevention, shoot for perfection

It really struck me today that it's the people who've chosen to compromise their prevention program who end up with trouble--heart procedures, heart attack, even heart failure.

Take Bob, for example. Bob is 73 years old and had a bypass operation in 2000. The procedure went well and Bob enjoyed 6 years of seemingly trouble-free life. Bob had a seriously low HDL cholesterol for which he as taken a modest dose of niacin, but was unwilling to do much more. His HDL cholesterol was thererefore "stalled" at around 40 mg. (We aim for 60 mg or greater.) We talked repeatedly about the options for increasing HDL but Bob was content with his results. After all, since his bypass operation, he'd felt well and could do all he wanted without physical limitation.

But Bob underwent a stress test for surveillance purposes (which we routinely do 5 or more years after bypass surgery). The test was markedly abnormal with two major areas of poor blood flow to his heart (signalling potential heart attack in future). Bob ended up getting 5 stents to salvage two bypass grafts, both of which showed signs of substantial degeneration.

I've seen this scenario repeatedly: A person is unwilling to go the extra mile to obtain perfection in lipid/lipoprotein patterns, lifestyle changes, and taking the basic, required supplements. Compromises eventually catch up to you in the form of another heart attack, more procedures, heart failure, physical disability, even death.

The message: Don't draw compromises in heart disease prevention. Coronary plaque is a chronic process. It will take advantage of you if you ever let your guard down.

The epidemic of small LDL

Of the patients I saw in my office yesterday, virtually EVERYONE had small LDL.

Small LDL is emerging as an extraordinarily prevalent lipoprotein pattern that drives coronary plaque growth. Previous estimates have put small LDL as affecting only 20-30% of people with coronary disease. However, in my experience in the last few years, I would estimate that greater than 80% of people with measurable coronary plaque have small LDL.

If you have a heart scan score >zero, chances are you have it, too.

I call small LDL a "modern" disease because it has skyrocketed in prevalence recently because of the great surge in inactivity in Americans.

When's the last time you walked to the grocery store and back, lugging two bags of groceries? How many years has it been since you've push-mowed your lawn? All the small conveniences of life have permeated further and further into our activities. Most of us spend the great majority of our day right where you are now--on your duff.

On the bright side, small LDL in most people is reducable by simply getting up and going. But the old teaching of 30 minutes of activity per day is now outdated. This was true when the other hours of your life included physical activities, like housework or a moderately active job. However, if the other 23 1/2 hours of your day are sedentary, then 30 minutes a day won't do it. An hour or more of activity, whether exercise or physical labor of some variety will get you better small LDL-suppressing results.

For most people with small LDL, fish oil and niacin are also necessary to fully suppress small LDL to the Track Your Plaque goal of <10 mg/dl.

A great discussion on vitamin D

If you need better convincing that vitamin D is among the most underappreciated but crucial vitamins for health, see Russell Martin's review of vitamin D and its role in cancer prevention. You'll find it in March, 2006 Life Extension Magazine or their www.LEF.org website at:

http://search.lef.org/cgi-src-bin/MsmGo.exe?grab_id=0&page_id=1308&query=vitamin%20d&hiword=VITAM%20VITAMER%20VITAMERS%20VITAMI%20VITAMINA%20VITAMINAS%20VITAMINC%20VITAMIND%20VITAMINE%20VITAMINEN%20VITAMINES%20VITAMINIC%20VITAMINK%20VITAMINS%20d%20vitamin%20

Our preliminary experience over the past year suggests that vitamin D may be the crucial missing link in many people's plaque control program. We've had a handful of people who, despite an otherwise perfect program (LDL<60, HDL>60, etc.; vigorous exercise, healthy food selection, etc.--I mean perfect)continued to show plaque growth. The rate of growth was slower than the natural expected rate of 30% per year, but still frightening rates of 14-18% per year--until we added vitamin D. All of a sudden, we saw dramatic regression of 7-25% in 6 months to a year.

This does not mean that vitamin D all by itself regresses plaque. I believe it means that vitamin D exerts a "permissive" effect, allowing all the other treatments (fish oil, LDL reduction, HDL raising, correction of small LDL, etc.) to exert their full benefit. So please don't stop everything and just take D. This will not work. However, adding vitamin D to your program on top of the basic Track Your Plaque approach--that's the best way I know of.

MSNBC Report: We need more heart procedures!

A recent headline from MSNBC by Robert Bazell reads:

NEW YORK - Angioplasty, bypass surgery and cholesterol-lowering medications are among the many interventions that have brought a sharp decrease in heart disease deaths in recent years. But, as Dr. Sharon Hayes of the Mayo Clinic points out, there is one big problem.

“The death rates in women have not declined as much as they have in men,” she says.

The piece goes on to suggest that women are getting short-ended in the diagnosis of heart symptoms and heart attack. The solution: More testing to assess the need for procedures like bypass.

This is typical of the device and medication-dominated media consciousness: More procedures, more medication, more devices. Who's paying for advertising, after all? The money at stake is huge. But is this what you want?

Don't be swayed by media reporters with limited understanding of the real issues (at best), consciousness of who's paying for advertising (at worst). Yes, heart disese is often underestimated or misdiagnosed in women. The answer is better detection earlier in life followed by efforts to halt the process--effective, safe treatments for people's benefit, not just profit.

What role cholesterol medication?

A frequent conversation point among my patients, as well as participants in the www.cureality.com program, is "Are cholesterol medications really necessary?"

No, they are not. What IS necessary is to correct all manifest and hidden causes of coronary plaque. Among these causes, in my view, is LDL cholesterol of 60 mg/dl or greater. There are many other causes of coronary plaque--e.g., small LDL particles, unrecognized hypertension, Lp(a), hidden diabetic patterns, etc.--but reducing LDL to 60 mg is still an important part of a plaque-reversing effort.

Insofar as we wish to get LDL to this goal, the statin cholesterol drugs like Lipitor, Zocor, Crestor, etc. may play a role. However, they should only be considered after a full effort dietary program is pursued. Don't follow the American Heart Association's diet unless you want to fail. It's nonsense.

For a more detailed discussion of how to use nutrition and nutritional supplements to reduce LDL cholesterol, go to www.lef.org, the website for the Life Extension Foundation. I wrote an article for their magazine called "Cholesterol and Statin Drugs: Separating Hype from Reality". You'll find the article at http://search.lef.org/cgi-src-bin/MsmGo.exe?grab_id=0&page_id=1295&query=davis%20cholesterol%20natural&hiword=CHOLESTEROLA%20CHOLESTEROLS%20DAVI%20DAVID%20DAVIE%20DAVIES%20DAVIN%20DAVIO%20DAVISON%20DAVISS%20DAVIT%20NATURALBASED%20NATURALES%20NATURALIZED%20NATURALLY%20NATURALS%20NATURE%20NATURES%20cholesterol%20davis%20natural%20.)

Can your plaque-reversal efforts succeed without statin drugs? It depends on your causes. For instance, someone with small LDL and Lp(a) only may do great on our basic program and then add niacin. Unfortunately, another person with a starting LDL cholesterol of 240 mg/dl--sky high--will have more success with these drugs.

Believe me, I am no blind supporter of drug companies and their flagrantly profit-seeking practices which, in my view, are cut-throat, shoving anyone and anything out of their way to increase profits and market share. I share many of Dr. Dave Warnarowski's views on how vicious their tactics can be; see his recent Blog post at http://www.drdavesbest.com/blog/ called "I smell a rat".

Nonetheless, the deep and well-funded research of the pharmaceutical industry does yield some useful tools. You don't have to love the insect exterminator, but if your house is being eaten by termites, his services can be useful. Same thing with these drugs. Useful--not the complete answer, not even close, but nonetheless useful in the right situations. Sometimes antibiotics are necessary, even life saving. That's how cholesterol drugs are, too.

Take it all in the proper perspective. Your goal is not cholesterol reduction, per se, but plaque control, preferably reversal.

Supplement Mania!

Ever hear of "polypharmacy"? That's when someone takes too many medicines. People will have lists of 15-20 prescription medicines, for instance, with crazy interactions and oodles of side-effects.

Well, how about "poly-supplments"? That's when someone takes a large number of nutritional supplements.

Let me tell you about a 45 year old man I met.

In an effort to rid himself of risk for heart disease that he felt was likely shared with his family (brother and father diagnosed with heart attacks in their late 40s), Steve followed a program of nutritional supplementation. You name it, he took it: hawthorne, anti-oxidant mixtures, vitamins C, E, B-complex, saw palmetto, 7-keto DHEA, velvet deer antler, gingko biloba, policosanol, chronium picolinate, green tea, pine bark extract, St. John's Wort, CoEnzyme Q10, papain and other digestive enzymes...He became a distributor for a nutritional supplement company to allow him to afford his own extraordinary program.

To satisfy himself that he had indeed "cured" himself of heart disease, he got himself a CT heart scan. His score: 470, in th 99th percentile. Steve's heart attack risk based on this score was around 10% per year. High risk, no question.

For weeks after his scan, Steve admitted walking around in a daze, not knowing what to do. Years of telling himself that he had effectively dealt with his heart disease risk, now all down the drain.

When we met, I persuaded him that to think that this collection of supplements would reverse heart disease was magical thinking. We trimmed his list down to the essentials and got him on the right track.

Heart disease is controllable and reversible, but not this way. Don't fool yourself into thinking that some collection of supplements will be enough to stamp out your heart disease risk. Just like taking an antibiotic when you don't have an infection achieves nothing, so does taking the wrong supplements.

What does heart scanning mean to you?

CT heart scans can mean different things to different people.


What does a heart scan mean to you? There are several possibilities:

1) A way of reducing uncertainty in your future.

2) A tool to crystallize your commitment to health.

3) A device to help you track how successful your heart disease prevention program is.

4) A trick to get you in the hospital.

5) A moneymaking tool for unscrupulous physicians hoping to profit from "downstream" testing, particularly heart catheterizations.


Like anything, heart scans can be used for both good and evil. How can you be sure that your heart scan is put to proper use--for your benefit and not someone else's profit?

Simple: Get educated. Understand the issues, be armed with informed questions.

If, for instance, you're a 55-year old female with a heart scan score of 90, active without symptoms, and you're told to have a heart catheterization right off the bat---run the other way. This is bad advice. A heart procedure like catheterization at this score in an asymptomatic woman is very rarely necessary. That decision can only be made after a step-by-step series of decisions are made by a truly interested, unbiased party. (A stress test is almost always required in this situation before the decision can be made to proceed with a catheterization.)

Unfortunately, in 2006, getting unbiased advice from your doctor is still a struggle. That's why we started Track Your Plaque---unbiased information, uncolored by drug or device company support, with an interest in the truth.

Coronary disease is drying up!

I had an interesting conversation with a device representative this morning. He was a sales representative for a major medical manufacturer of stents, defibrillators, and other such devices for heart disease.

Since I'm still involved with hospital heart care and cardiac catheterization laboratories, this representative asked me if I was interested in getting involved with some of the new cardiac devices making it to market over the next year or two. "The coronary market is drying up, what with coated stents and such. We've got to find new profit sources."

Well, doesn't that sum it up? If you haven't already had this epiphany, here it is:

HEART DISEASE IS A PROFITABLE BUSINESS!

Why else can hospitals afford billboards, $10 million dollar annual ad campaigns, etc.? They do it for PROFIT. Likewise, device and drug manufacturers see the tremendous profit in heart disease.

The representative's comments about the market "drying up" simply means that the use of coated stents has cut back on the need for repeat procedures. It does NOT mean that coronary disease is on the way out. On the contrary, for the people and institutions who stand to profit from heart care, there's lots of opportunity.

Track Your Plaque is trying to battle this trend. Heart disease should NOT be profitable. For the vast majority of us, it is a preventable process, much like house fires and dental cavities.

Mammogram for your heart

With the booming popularity of "64-slice CT scans", there's a lot of mis-information about what these tests provide.

These tests are essentially heart scans with added x-ray dye injected to see the insides of the arteries. However, to accomplish this, a large quantity of radiation is required. In addition, the test is not quantitative, that is, it is not a precise measure that can be repeated year after year.

It is okay to have a 64-slice CT coronary angiogram. It is NOT okay to have one every year. That's too much radiation. However, a heart scan can be repeated every year, if necessary, to track progression or regression. Once stabilization (zero change) or reduction is achieved, then you're done (unless your life takes a major change, like a 20 lb weight gain).

The tried-and-true CT heart scan is the gold standard--easy, inexpensive, precise, and repeatable. Not true for 64-slice angiograms.

Is your doctor using "leeches"?

What if you went to your doctor for a problem and he/she promptly placed leeches on your body?

Yeccchhhh! Would you go back? I'd bet that you'd run the other way as fast as your bleeding legs could take you. Outdated health practices like "bleeding" are outdated for good reason.

Then why would you allow your doctor to approach your heart disease prevention program by checking cholesterol and then waiting for symptoms to appear? That miserable approach leads to tragedy and death all too often--ask Bill Clinton! He might as well have had leeches!

Don't allow your doctor's ignorance or disinterest impede your prevention program. Get your coronary plaque measured, then attack it from all sides by knowing all causes, hidden and obvious. That's why Track Your Plaque is such an effective program.

I often wonder why more doctors aren't using this unbelievably powerful approach to deal with heart disease. But when I see colleagues implanting stents, defibrillators, and the like for many thousands of dollars per patient, the answers are obvious. Given a choice of a rational, effective program of prevention that pays the doctor a few hundred dollars for his time, versus $2000 to $10,000 for a procedure, you can see that the temptation is irresistible for many physicians.
Construct your glucose curve

Construct your glucose curve

In a previous Heart Scan Blog post, I discussed how to make use of postprandial (after-meal) blood sugars to reduce triglycerides, reduce small LDL, increase HDL, reduce blood pressure and inflammatory measures, and accelerate weight loss.

In that post, I suggested checking blood glucose one hour after finishing a meal. However, this is a bit of an oversimplification. Let me explain.

A number of factors influence the magnitude of blood glucose rise after a meal:

--Quantity of carbohydrates
--Digestibility of carbohydrates--The amylopectin A of wheat, for example, is among the most digestible of all, increasing blood sugar higher and faster.
--Fat and protein, both of which blunt the glucose rise (though only modestly).
--Inclusion of foods that slow gastric emptying, such as vinegar and fibers.
--Body weight, age, recent exercise

Just to name a few. Even if 10 people are fed identical meals, each person will have a somewhat different blood glucose pattern.

So it can be helpful to not just assume that 60 minutes will be your peak, but to establish your individual peak. It will vary from meal-to-meal, day-to-day, but you can get a pretty good sense of blood glucose behavior by constructing your own postprandial glucose curve.

Say I have a breakfast of oatmeal: slow-cooked, stoneground oatmeal with skim milk, a few walnuts, blueberries. Blood glucose prior: 95 mg/dl. Blood glucose one-hour postprandial: 160 mg/dl.

Rather than taking a one-hour blood glucose, let's instead take it every 15 minutes after you finish eating your oatmeal:


In this instance, the glucose peak occurred at 90-minutes after eating. 90-minute postprandial checks may therefore better reflect postprandial glucose peaks for this theoretical individual.

I previously picked 60-minutes postprandial to approximate the peak. You have the option of going a step better by, at least one time, performing your own every-15-minute glucose check to establish your own curve.

Comments (24) -

  • Eric

    2/19/2011 5:03:57 AM |

    Have you ever used a DexCom 7, like Tim Ferriss did for the 4 Hour Body book?

  • Kurt

    2/19/2011 12:55:16 PM |

    There is evidence that alcohol decreases the blood glucose rise, which may explain in part why moderate drinkers have lower risk of heart attacks. Have you found this to be true?

  • Anonymous

    2/19/2011 3:01:47 PM |

    With all respects, Doctor Davis, but I am at a loss to understand your reasoning behind the suggestion of constructing a 2-hour curve with readings taken every 15 minutes. Invariably after eating, blood glucose level will rise and then fall over the two-hour period. I can control the severity of the "spike" by the type of food I consume. After eating however, I cannot control the shape of the curve without the intervention of medication or physical exercise. This is known. So what additional practical information is provided me from this exercise?
    My regards, StanO

  • Anonymous

    2/19/2011 3:09:36 PM |

    Hi! These are my readings using a 1-low carb meal-day approach during months.

    day   hour mg/dL
    02/15 11:17 74
    02/15 12:57 83
    02/15 13:53 79
    exercise lifting weights
    02/15 15:11 93
    end of exercise
    02/15 15:46 75
    02/15 16:22 86
    02/15 16:49 83
    meal time

    As you can see these are my pre-meal levels in a low carb diet, one meal a day approach eating nuts, yogurt, liver, meat, fish, especial atkins bread, butter, chicken, eggs etc..

    Next day I change my normal low carb meal for a high carb meal (pasta with a bit of meat) with my morning sugar in these same levels. Lets the party begin.

    02/16 13:20 finish pasta festival
    02/16 13:29 114
    02/16 13:42 103
    02/16 13:57 125
    02/16 14:06 127
    02/16 14:12 137
    02/16 14:23 119
    02/16 14:36 126
    02/16 14:48 130
    02/16 15:03 123
    02/16 15:15 106
    02/16 15:30 112
    02/16 15:46 111
    02/16 16:11 107
    02/16 16:22 105
    02/16 16:47 114
    02/16 17:21 121
    02/16 17:32 120
    02/16 18:07 113
    02/16 18:21 125
    02/16 18:50 110
    02/16 19:42 114
    02/16 20:21 130
    02/16 21:29 112
    02/16 23:37 119
    time to bed. I also feel like shit.

    Next day, do you think the party is over?

    02/17 07:20 121 (no)
    02/17 12:15  71 (finally, nearly 24 hours of high sugar levels!)
    02/17 13:00  84
    02/17 14:50  81
    02/17 15:57  71
    02/17 16:30  end meal (with a bit of wheat bread)
    02/17 16:48  99
    02/17 17:08 111
    02/17 17:27  94
    02/17 17:47  82
    02/17 18:18  87
    02/17 18:42  73
    02/17 20:09  78
    exercise (please, do not ask what type of exercise and how I can manage to check my sugar in that situationSmile
    02/17 21:31  98
    02/17 22:01  97
    end of exercise
    02/17 23:15  88
    02/17 00:38  83

    Next day

    02/18 09:18 79
    02/18 10:36 81
    02/18 11:38 85
    exercise (ski, more aerobic so my sugar levels do not increase to much. Cannot use the sticks due to low temp)
    02/18 18:00 80
    low carb meal using  whole grain special atkins bread
    02/18 18:31 85
    02/18 18:47 98
    02/18 19:08 90
    02/18 19:30 88
    02/18 19:45 93
    02/18 20:20 87
    02/18 20:40 80
    exercise
    02/18 21:12 92
    02/18 21:58 94
    02/18 22:26 91
    end of exercise
    02/18 23:39 88
    02/18 01:17 88
    exercise
    02/18 02:20 93
    end of exercise

    Next day similar to my first set of data.

  • Geoffrey Levens

    2/19/2011 5:01:08 PM |

    "I am at a loss to understand your reasoning behind the suggestion of constructing a 2-hour curve"

    Varies so much per person and meal composition.  Some people will get peak even longer than two hours w/ something like pizza that has lot of heavy grease as well as the carbs.  Or if they have any gastroparesis  issues

  • Dr. William Davis

    2/19/2011 7:05:00 PM |

    Hi, Eric--

    Sorry, but I don't know what DexCom 7 is. Can you tell me anything about it?


    Hi, Kurt--

    The effects of alcohol and alcoholic beverages are complex. The blood sugar effect is only a small part of the equation. Among the most consistent effects are reduced blood sugar with red wine, increased blood sugar with beer.

  • Dr. William Davis

    2/19/2011 7:07:12 PM |

    Hi, Anonymous--

    Impressive effort!

    Incredibly, just about any primary care doc would declare your values "normal," since you don't "need" medication.

    You've found the secret: Carbohydrates screw up health galore.

  • STG

    2/19/2011 10:54:14 PM |

    I almost had a wheat relapse today, but what I realized is that I wanted the butter. So, I ate a small bite of organic butter.

  • revelo

    2/20/2011 1:01:30 AM |

    Carbohydrates don't screw up health in most people, but they have to be managed properly. Anonymous's glucose spike occurred because he/she surprised the body with a heavier carb load than it was adapted to. It takes a week or so for the body to upregulate insulin sensitivity and glycogen storage ability. Until that upregulation occurs, high carb intake will indeed cause glucose spikes.

    Here's my own anecdote. After switching to a paleo diet for a week, I then switched back to high-carb. Upon eating 200g (dry) of cooked oats, my glucose shot up to 195 mg/dL. A week later, I was able to eat the same 200g (dry) of cooked oats and glucose remained below 120 mg/dL. What happened is that my ability to process glucose downregulated when I switched to paleo, then upregulated after I switched back to high-carb. Both the down and upregulation take a few days. It is probably inadvisable to constantly switch between paleo and high-carb. If you plan to eat high-carb, then do so consistently, so that the body is always prepared for high glucose loads.

    My recent VAP blood tests, taken after resuming my usual high-carb regimen, show HDL=66 mg/dL, LDL=61, VLDL=12, Trig=45, Lp(a)=15, HDL-2=23 (most protective HDL greater than Lp(a), thus counteracting the latter), and type A LDL pattern (mostly large buoyant LDL). CRP was .16mg/L, which is very low. Laboratory measurement of fasting glucose was 85 mg/dL, versus 84 for Reli-On Confirm home glucose testing device measured that same morning (the Reli-On device thus appears to be accurate). These results hardly suggest that a high-carb diet necessarily screws up health.

    There is also plenty of other evidence that carbs are not unhealthy for people who are lean, get daily exercise, don't have an underlying illness, and eat mostly unrefined carbs. All sorts of primitive peoples (Kitavans, Tarahumara indians, Bantus,  traditional mediterranean people's, etc) eat high-carb diets and have very low incidence of diabetes, heart disease and other chronic illnesses due to diet (they may have chronic illnesses due to parasites).

  • Might-o'chondri-AL

    2/20/2011 1:17:59 AM |

    Depression a variable: Japan 2010 journal "Anti- Aging" showed affect on blood glucose in 5 hour glucose(75 grams) tolerance test on a clinic's depressed in-patient (woman age 36). The articles authors conclude a "very low saccharide diet" is better for the brain, which runs fine on ketones.

    Fasting blood sugar = 74
    30 min post glucose = 97
    1  hour  "    "     = 78
       (coincides with insulin peak)
    2 hour post glucose = 54
       (27% below fasting blood    
        sugar)
    3 hour post glucose = 99
       (insulin less than 1/2 of
        30 min. insulin & 1/3 of
         2 hour insulin)
    4 hour post glucose = 75
    5 hour "     "       = 80

  • Anonymous

    2/20/2011 2:04:08 AM |

    I have a big question here.
    I persoanlly have my peak at 30 minutes. So my question is:
    Is it a BG of 140-160 after 30 minutes if after 60 minutes it is under 100 too bad?

  • revelo

    2/20/2011 2:49:20 AM |

    @Might-o'chondri-AL: Can't understand the logic of low-carb for depressed people. High-carb boosts serotonin. The only reason I could think of prescribing low-carb for a depressed person is because they are overweight, and the excess weight is partly responsible for the depression (inability to move about and exercise due to morbid obesity, for example).

  • Anonymous

    2/20/2011 6:27:17 AM |

    revelo, thanks for some sanity.  Reading these blog posts and most of the comments that follow is depressing.  They would have everyone believe that their inability to handle carbs is representative of normal, healthy, individuals.

    Maybe they need to get healthy, and then they can actually eat whole-food sources of carbs and stop being so scared and go and live life.

  • Might-o'chondri-AL

    2/20/2011 8:30:25 AM |

    Hi Revelo,
    I've got nothing against carbs & am still learning (I eat carbs); your blood profile seems excellent enough to trade for.My thinking on your approach is: that you may find, like me in my 20/30/40s + years, care free
    carbohydrates are fine and by
    the time hit 60 there's the unforseen to adjust to. The famous quote is: "Old age ain't for sissys."
      
    So, back to Japan ....
    Psychiatric clinic tested 2,000;
    detailed one to show how variable blood sugar/insulin expression is in depression. They claim to have got her off meds and adressed low neuro-transmitters of depression; which clinically they say (depression) is common in metabolic syndrome.

    Their flow chart for seratonin is dietary amino acid L-tryptophan as substrate with folic acid, iron, niacin and enzyme tryptophan hydroxylase; yields, 5-HTP with vitamin B6 and enzyme 5-HTP decarboxylase; yields seratonin (which in it's own right is the substrate for
    magnesium and SAMe to make into melatonin). I'll skip their GABA and dopamine flow charts.

    This was a geriatric symposium paper, so focus was on brain down the line. Their pitch was for preventing cognitive decline;
    and that ketones protect the brain from Alzheimers and Parkinsons - just as ketones diets do help in
    epilesy and other mental disorders.

    They specify that in the brain beta-hydroxy-butyrate (ketone) ups utilization of circulating oxygen more, decreases CO2 in tissues from glucose "burning", and ketones make ATP more efficiently too. As for the mitochondria, they continue to get their essential glucose molecules from gluco-neogenesis.

    My impression is they're showing that in geriatrics the potential
    accumulation of what Doc's blog
    warned about, namely  A.G.E.s
    (advanced glycation endproducts)is a risk factor for Alzheimers, etc. The authors conclusion was the central nervous system used ketones just fine;and carbohydrates were not required for old people to have good levels of circulating blood sugar.





    sowed data for 1 depressed lady

  • Anonymous

    2/20/2011 11:43:35 AM |

    Dr Davis: Two comments were made asking for your reasoning behind the suggestion for construction of a 2 hr curve. To me the comments are politely made. They are appropriate in my opinion and they deserve a response. It is obvious that you chose deliberately to ignore them.

    Your commentary is followed and I expect influences countless readers; some possibly obsessively, ie healthy individual who performed more the 75 glucose checks over a few days time.

    With your efforts to maintain this blog come added responsibilities to its readers which you currently are ignoring.

    Shame on you.

  • STG

    2/20/2011 3:47:40 PM |

    Anonymous: Your response to this blog is somewhat emotional and critical. Perhaps you could be open to the idea that some people can consume a high, unrefined carbo diet and be healthy; others will suffer adverse effects on a high carbo diet and need a more protein based or mixed diet. For those individuals that are carbo sensitive, there is good dietary advise on the blog. I do not currently test my blood sugar. I do not want to become myopic about health; however,I don't judge others on this blog who want to pursue this strategy even if they are not insulin resistant, diabetic or pre-diabetic. Moreover, I may have to resort to using a monitor in the future. The blood sugar data from another "anonymous" is very interesting and certainly provides real data for determining his or her dietary choices. Please keep an open mind and avoid insulting comments like "shame on you" which add nothing to the dicussion and are meant to insult not to educate or enlighten others.

  • Geoffrey Levens

    2/20/2011 4:38:32 PM |

    DexCom 7 is a "continuous" bg monitor for home use. http://www.dexcom.com/products

    I have been eating Dr Fuhrman's diet and lately, typical meal contains 3-4 cups chopped leafy greens, 2/3 cups cooked beans, about 2/3 oz raw seeds/nuts, 200 grams starchy root veg, one piece of fruit (most often an apple).  Peak postprandial sugars for me come very close to one hour after end of meal and are in low 120's to high hundred teens, back to fasting by 90-120 minutes Usually 90 minutes).

  • joseph

    2/20/2011 4:54:29 PM |

    why do you think that post meal levels of 120 or 140 are "normal"? Simply because are the levels that people get when eat a lot of carbs in a meal.

    You body do not like this levels, that is why it try to put them down using insulin. Why is your body doing that if they are "normal levels"?

    If you check my levels in the 4 reply you could find that when you do not eat for longs periods of time your body try keep your sugar between 70 and 90. If you are relaxed the level could be in the 70 zone and if you do some exercise it will go to 90 zone. Why your body do no increase it to "normal levels" of 120-140? Probably because this levels are not "normal".

    So you have a high carb meal. Your body react to it trying to keep your sugar down, why?. Yes... your body is stupid and doesn't have a degree in nutrition so cannot understand the science behind this "normal levels".

    When you body finally got the 85 level your dietitian says that you need to have another high carb meal. So your levels return to 120-140, and you ignorant body starts to reduce this "normal level" to 70-85. When you got that level is time to have another high carb meal, and your ignorant body returns to do the same trick.

    Years of doing that and your body cannot maintain the true normal levels your doctor says that you need to do some exercise to well... reduce sugar levels! and of course still doing 5-6 small high carb meals a day.

    So now you need to run the New York City Marathon to get rid of all that carbs in all that meals your are eating during the day.

    Of course you need increase the carbs in these meals to have energy to do all that exercises. In one of those healthy marathons you also take a high carb drink to... well... you know.

    It doesn't work, you end eating more than before because your body needs more energy to run all that healthy marathons and you are all the day hungry.

    Later your unscientific and stupid  pancreas collapse and your doctor says that you need to maintain your 34646464 high carbs meals a day, but take some insulin to help your body to reduce all the sugars YOU ARE EATING EVERY 3 HOURS.

    Probably our pancreas simply commit suicide because is not able to understand our rock solid science.

  • Anonymous

    2/20/2011 5:15:30 PM |

    Can someone explain to a non-scientist what "up-regulate" and "down-regulate" mean?  Peter

  • Anonymous

    2/21/2011 1:38:04 AM |

    A couple of people have asked why construct your own glucose curve so I thought I'd throw out my thoughts on it.  Every person's glucose will peak at different points either due to slower stomach emptying or a slower absorbed carb or whatever. I have read that many people will peak at 75 minutes.  So if you are trying to get a real idea as to how your body reacts to glucose/insulin then you need to test frequently to find YOUR personal peak.  Then you will know when to test when you try new foods.  Is that others understanding too?
    Char

  • Anonymous

    2/21/2011 3:21:29 AM |

    This blog post is so full of Fear, Uncertainty, and Doubt.  People asking questions due to being scared by Dr. Davis' suggestion of "constructing your glucose curve", so they ask him questions in the comments, like what their "glucose curve" should look like.  People thinking now they better be jabbing themselves 15 times after a meal.  Thinking about a meal for hours after a meal.  Guilt for eating that meal.

    So Dr. Davis' response?  IGNORE THEM and put up a new blog post with MORE scare-mongering:


    Now you should fear the banana!
    http://www.heartscanblog.org/2011/02/american-heart-association-diet-makes.html

    "Would you like a banana?"


    What a joke.  Show us a single person who got fat off of bananas OR potatoes, or any whole food carbs.

  • Might-o'chondri-AL

    2/21/2011 5:10:31 AM |

    Hi Peter,
    Up-regulate is an action on a gene that makes it do more of what it's capable of doing. And down-regulate is when a gene is being acted on in a way that it will do less of what it's capable of doing.

    A gene can be overactive or underactive. Depending on the dynamic, of how a specific gene ideally should be doing, regulation up or down is desired.

  • eye lift guide

    2/22/2011 9:34:34 AM |

    Here is giving nice tips. Thanks for its. I the way you explain us.

  • Dr George

    3/29/2011 7:35:53 AM |

    Hey there Dr Davis,

    Created my own glucose curve as part of my own research and actually got a bit of a scare!

    I was doing a high carb meal to try and demonstrate an early carb spike then drop.

    While I didn't get the response I was looking for I got something a bit scarier. A fasting glucose indicitive of pre-diabetes reading instead. I am amazed how one bad meal was able to send my sugar awol over night.

    Back onto low carbs for me.

    Thanks for helping open my eyes to my potential diabetes.

    Dr George

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