Success--Slow but sure

John is a gentleman.

At age 76, he continues to teach at a local college. He's a delight to talk to, having written several scholarly books on religious topics. He's a fountain of knowledge on religious history and the roots of faith.

John is one of those incurably optimistic people, always greeting me with a smile and a warm handshake. I can't help but linger for a hour or so to talk with John, unfortunately disrupting my office schedule miserably.

John is another Track Your Plaque success story. Though he didn't set any records in reduction of his heart scan score, he did it simply by adhering to the program over a period of two years, succeeding slowly but surely.

John's first heart scan score: 1190, a score that carries as much as a 25% annual risk for heart attack. Among the list of causes was an LDL cholesterol in the 170 mg/dl range, along with an LDL particle number that verified the accuracy of LDL.

Among John's suggested treatments was a statin drug, since I was not confident he could reduce LDL with diet and nutritional modifications sufficiently to safely reduce both LDL and his risk for heart attack. But he proved terribly intolerant to any dose of any statin, with incapacitating and strange side-effects, like head-to-toe itching, abdominal cramps and diarrhea. It was clear: John needed to do the program without benefit of a statin drug.

I therefore asked John to maximize all efforts that reduce LDL, 70% of which were small LDL paricles despite his very slender build. He used oat bran and ground flaxseed daily, raw nuts, a soy protein smoothie every morning, and eliminated wheat and other high-glycemic index foods (including the Oreos he loved to snack on). Because the mis-adventures with statin drugs wasted nearly a year, I asked John to undergo another heart scan. Score 2: 1383, a 16% increase.

I asked John to keep on going. Thankfully, he did manage to tolerate fish oil, niacin (though it required over a year just to get to a 1000 mg per day dose), and vitamin D. With all these efforts, he did reduce LDL to the 80-90 mg/dl range. Of course, John's unflagging optimism was crucial. He did express his occasional anxiety over his heart scan score, but dealt with it in a logical, philosophical way. He understood that there was no role for prophylactic stents or bypass, and he accepted that much of his program rested on his ability to adhere to the strategies we advised.

Another year later, a 3rd heart scan: 1210, a 12% reduction.

I'm very proud of John and his success. When you think about it, he succeeded in conquering heart disease with some very simple tools, minus statin drugs. It can be done, but requires consistency and patience--and an optimistic outlook.

Comments (5) -

  • katkarma

    10/12/2007 6:37:00 PM |

    I try to follow your regimen of Fish Oil, Vitamin D, niacin and eat oat bran w/flax seeds also, but I use whey protein shakes in the morning because of the taste.   Is  this amount of soy really helping to lower LDL?  Is whey protein ok to use?

  • Dr. Davis

    10/13/2007 1:51:00 AM |

    Yes, I believe whey is fine.

    The LDL-reducing effect of soy is very modest, usually no more than 10 mg/dl. I like it because of the protein that permits low-glycemic index foods to be created with it. I also grew up with soy products since I was a kid and am very comfortable with its many forms.

  • wccaguy

    10/13/2007 2:17:00 AM |

    Just to follow up on katkarma's question...

    Is there any reason to use soy protein rather than whey protein other than that modest LDL lowering effect?

    Any reason not to use whey protein as a surrogate for soy protein?

  • Dr. Davis

    10/16/2007 10:52:00 PM |

    To my knowledge, whey protein is fine, though without direct effects on such things as LDL/small LDL.

  • Scott Parrish

    10/17/2007 1:09:00 PM |

    Kaayla Daniel, in her book "The Whole Soy Story," makes the best for avoiding soy unless fermented. Fermented options including natto, miso, tempeh, but NOT soy protein isolate, tofu, soy milk and other popular soy forms. Problems with soy include estrogenic activity, certain mineral absorption problems, thyroid problems, increased risk for certain cancers.

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Is skinny necessary for reversal?

Is skinny necessary for reversal?

Nothing we do in the Track Your Plaque program guarantees that coronary atherosclerotic plaque or your heart scan score is reduced or reversed.



But everything we do weighs the odds in your favor of successfully achieving reversal: correction of lipoprotein patterns, uncovering hidden patterns like Lp(a), vitamin D, being optimistic--it all tips the scales in your favor.

But how necessary is it to be skinny, meaning somewhere near your ideal weight?

It is important, but not as important as it used to be. Let me explain.

I used to tell people that plaque would not regress unless ideal weight was achieved and all the parameters of abdominal obesity and metabolic syndrome were corrected. This includes blood pressure, blood sugar, low HDL, small LDL, high triglycerides, and high c-reactive protein. Curiously, though, as we've gotten better and better at reducing coronary calcium scores, I've been finding that complete correction of all parameters, including achieving ideal weight, don't seem to be as necessary to achieve plaque reversal.

I almost hate to say this, but I've even witnessed significant drops in heart scan scores in people with body mass indexes (BMI) of 30--obese.

The necessary change doesn't seem to be weight, per se, but the consequences of weight. In other words, if you remain overweight, but blood sugar, HDL, small LDL, etc. have shown substantial improvement, then reversal is still achievable.

Then is it okay to be fat or overweight?

Reducing weight to ideal weight does indeed tip the scales in your favor, since it represents an observable, perceptible measure of all associated patterns. Dropping weight can also minimize the need for efforts to correct the consequences of overweight--you might need less niacin, fish oil, exercise, blood pressure medication, etc. to succeed at plaque reversal. Achieving ideal weight may also provide benefits like reduced risk of cancers and degenerative diseases of the hips and knees. But, to my recent surprise over the last two years, achieving ideal weight is not an absolute requirement to achieve reversal.

This is contrary to what some others say. For instance, in an upcoming interview with Dr. Joel Fuhrman on the Track Your Plaque website, Dr. Fuhrman argues that 10% body fat for males, 22% body fat for females, accelerates plaque and symptom reversal. Dr. Fuhrman is author of Fasting and Eating for Health, Eat to Live, and a new upcoming 2-part book, Eat for Health, and proponent of high-nutrient vegetarian diets and fasting. Dr. Fuhrman has been helpful in teaching us some important lessons on how to apply periodic fasting to accelerate plaque reversal.

So, which is it, fat or skinny?

If given a choice (which everyone has), I'd choose skinny. But, provided all the parameters associated with overweight are corrected, then remaining overweight doesn't necessarily mean that you can't still succeed at plaque reversal.

If you are interested in knowing what your ideal weight is, there are a number of software calculators and tables available, including the HealthCentral.com calculator and the National Heart, Lung, and Blood Institute BMI Calculator.


Image courtesy Wikipedia.

Copyright William Davis, MD 2008

Comments (19) -

  • Nancy M.

    1/6/2008 9:25:00 PM |

    It all falls in line with obesity being another marker for an overall metabolic condition, not being the *cause* of the metabolic condition.  

    The biggest disservice the medical establishment has done is ignore the evidence of this and continue to prescribe a diet that just makes it all worse and worse.

    I'm glad you're spreading the good word!

  • Peter

    1/8/2008 1:32:00 PM |

    Hi Dr Davis,

    Another cracking post. It reminds me distinctly of a long discussion on Dr Bernstein's site as to whether weight loss to ideal weight is needed to normalise blood sugars in a type 2 diabetic. You appear to be looking at another aspect of the metabolic syndrome, IHD. And it appears to be quite obvious that weight loss, per se, is irrelevant to both IHD and normoglycaemia, PROVIDED you normalise the problems described as the metabolic syndrome.

    Furnham and fasting is equally interesting. One has to ask; what happens during fasting? A full water fast to might be expected to give up to a kilo of weight loss each week perhaps? I've never tried this, but would guess this is reasonable. With flat-line basal glucose and insulin levels. That's just under 150g/d of weight loss, of which perhaps at least 100g/d is body fat. Mostly palmitic acid with some palmitoleic thrown in.

    The fat does not just evaporate. This is what a person's metabolism runs on during fasting. Mostly saturated fat. And fasting is excellent for plaque reversal, we're told. And I believe it.

    The question to me is, what would happen if you replaced that lost fat, by mouth, with similar fat (palmitic and palmitoleic, ie lard) to produce weight stability? Would you continue reversal without fasting? Perhaps throwing in 50g/d high quality protein to stop muscle loss.

    Obviously anyone on a low fat diet, needing to maintain weight stability, requires a high carbohydrate intake with its associated and inevitable post prandial hyper-insulinaemia. No insulin, no glucose uptake. We need calories to live. 1000kcal of lettuce needs insulin for every molecule of glucose it releases. Once a low fat vegan has lost their palmitic acid based excess weight, they'll be right back on to glucose based metabolism.

    Fasting is fat fueled. It works for reversal. Whether from your adipocytes or your plate, it's the same palmitic acid.

    Peter

  • Dr. Davis

    1/8/2008 1:39:00 PM |

    Hi, Peter-

    Interesting thoughts.

    It makes me wonder again whether there are ways to accelerate the process of plaque reversal. While we typically achieve it in a 12-18 month long timeline, could it be achieved in a less than 4 week period? Could we do so by using specific nutrient manipulations during fasting?

    I don't know, but I'm hoping that we can inch towards some insight towards this process.

  • Anonymous

    1/8/2008 3:26:00 PM |

    It's pretty strange seeing you promoting a Vegan doc...flies in the face of much of what you've been talking about.  And water-only fasts are tremendously muscle-wasting.

  • Dr. Davis

    1/8/2008 3:47:00 PM |

    I'm not promoting anybody.

    I am entertaining interesting concepts from people who provide unique or differing views.

    Coronary disease is potentially a life-threatening disease. If I need to sacrifice some recoverable muscle mass in order to substantially control or reverse it, then it's a small price to pay.

  • Peter

    1/8/2008 8:30:00 PM |

    Anonymous,

    If I could just clarify my own opinion:

    A vegan on a water fast, after the first 2 days, is living on animal fat and animal protein. Their own. They will obviously die if they continue, although possibly without arteriosclerosis (makes you think of Pritkin). Supplying that same person with 150g of lard and 9 whole eggs (biologically eggs are the highest value protein according to the WHO) per day will provide the same metabolic conditions as fasting without the fasting, weight loss or muscle loss. The question then is whether this will continue the rapid reversal of arteriosclerosis. That is open to debate, and no doubt we all will have our opinions. I invite the use of logic. I've said before, I visit here as Dr Davis is open to ideas which do not necessarily tally with his own. That's good.

    Peter

  • wccaguy

    1/9/2008 2:14:00 AM |

    Dr. Davis,

    I'm not a doctor or a scientist so what do I know?  nothing...  And I'm probably not going to restate Peter's argument very well.

    But it seems to me that in the rethinking of diet that you're engaged in, partially triggered by the Taubes book, you're going to need to address this argument that Peter makes.  I had never heard that argument before but I can't think of an escape from the logic of it, namely:

    1) during fasts, plaque regresses, 2) during fasts, body fat (which Peter says is mostly saturated fat) is used to provide energy, but 3)  how could plaque regress if a metabolism running on saturated fat was harmful to that regression process?

    It would be very interesting to hear what Dr. Fuhrman thinks about this too.

  • Dr. Davis

    1/9/2008 3:26:00 AM |

    Hi, WC--

    I don't have a pat answer for you, but I think the conversation opens up some very fascinating avenues for further thought and exploration.

    Of course, fatty acids do not just enter and exit cells passively depending on concentration gradients, but do so under the control and influence of a number of factors.

    Nonetheless, I think we are onto something, this idea of "enhanced fasting" to achieve accelerated reversal. Hmmmm....

  • chickadeenorth

    1/9/2008 5:52:00 AM |

    Just a thought, don'T know if its related or not....When people stalled out on weight loss Atkins suggested a fat FasT for 4 or so days eating macadamina nuts,olives, egg salad with whole fat mayo,even a few T OF OLIVE OIL.It seemed to reboot the metabolism...don't know about plague reversal but it stopped hunger and people started to lose again, he said not too do this until the plateau was a month long, I cant recall exact time frames.
    Its so contrary to what we have been led to beleive but if I knew it would reverse my plague I would do it, but would have to see how to balance BG, maybe have to go off glucopaghe while doing it and monitor lots.

    Several on Bernsteins site fast alot in the week to regain control of bg.

  • wccaguy

    1/9/2008 11:30:00 AM |

    I read your new special report at  Track Your Plaque that is an interview with Dr. Fuhrman on fasting and had some thoughts.

    I confess that my head is still spinning by the argument that Peter has made in his comments to this post.

    When I first read Peter's argument, it reminded me more than anything else of the first paragraph of Gary Taubes' NYT Magazine article a few years back when he described the irony that would be many doctors standing naked in Times Square moment:

    Dr. Fuhrman, an ardent vegan, promotes fasting as a helpful solution for reducing plaque without realizing and surely without understanding that the reason the solution works is because it amounts to increased animal fat consumption.

    I have to say that I'm completely unimpressed by any explanation or theory Dr. Fuhrman's put forward, either in his first book or in his interview with you, about WHY fasting works to regress plaque or at least reduce angina symptoms.

    Am I missing something and he actually can and does explain why it works?

    Peter, on the other hand, has put a theory on the table about why it works that could be tested, right?  Or has it already been tested?

    If and when the moment comes when a lot of doctors are standing naked in Times Square, I'm going to be there with a camera.  lol

    As always Dr. D, thanks for the post and for attracting some great minds who make posts that are fascinating reads.

  • Dr. Davis

    1/9/2008 1:42:00 PM |

    To my knowledge, formal clinical research on the effects of fasting (i.e., controlled "starvation") are woefully limited. I know of no studies that examine the effects of specific nutrient feeding to fasting or starving subjects. But it would be fascinating.

  • Anonymous

    1/10/2008 2:33:00 PM |

    The other aspect in common between fasting and a very low-carb diet are the ketones. It might be that the ketones are responsible for a bettering of heart condition as it is most efficient fuel we can use.

    There is a difference though between them, one is catabolic the other is anabolic, so they may not be exactly equivalent.

    Just some random thoughts.

  • Dr. Davis

    1/10/2008 4:16:00 PM |

    What an interesting idea!

  • Peter

    1/10/2008 9:15:00 PM |

    Excellent point

    Yasiwaya points out that ketosis restores the mitochiondrial function lost in insulin resistance, best quote:

    "The ability of a physiologic ratio of ketone bodies to correct most of the metabolic defects of acute insulin deficiency suggests therapeutic roles for these natural substrates during periods of impaired cardiac performance and in insulin-resistant states"

    Some of the other papers by this author, available in full text by hitting "related links" suggest a deep in depth knowledge, but they're way beyond me.

    For those of us who long ago abandoned the cholesterol hypothesis, hyperinsulinaemia and insulin resistance are the driving forces of IHD. The Yudkin/Stout camp. Ketosis appears to side step insulin resistance, be that in the myocardium or the cells of the arterial media. I would wholely agree this is a useful step in IHD and may well be where the benefits come from.

    Peter

  • Dr. Davis

    1/10/2008 10:11:00 PM |

    I have to admit that I hadn't thought of ketosis as a process with its own health consequences, just as a consequence itself. This may be worth investigating!

  • Anonymous

    1/11/2008 2:26:00 PM |

    Dr Davis,  been meaning to mention, I've been informed that the company Vassol Inc, there web sight is http://www.vassolinc.com/, has succeeded in being able to scan the "moving" heart with an MRI machine.  I was told that the company is now working with the NIH in conducting further studies.  Thought you might find interesting as I imagine an MRI would be helpful with wanting to check quick progress on patients.

  • e4e

    8/8/2008 3:57:00 AM |

    Yeah but...

    Why use BMI? Why not use body fat directly instead?

  • Bruce K

    8/12/2008 7:30:00 PM |

    Peter, I would use butter, ghee, or beef fat instead of lard (2-4% PUFA vs 12%). You're wrong that eating a high lard diet would be the same as fasting. On a fast, you don't eat a gram of PUFAs. 150g of lard has 18g of PUFAs. 150g of beef tallow has 3 to 4.5 grams, or 1/4 to 1/6 as much as lard. Ruminant animals are best. Also, eggs are unnecessary. You can eat fat from meat, butter, and some organ meats every now and then. The eggs have more than PUFAs than beef and butter fat. To really reproduce the fasting state, I would keep the PUFAs as low as possible (3-4g).

  • Anonymous

    1/31/2011 5:44:48 AM |

    Fasting induces autophagy, a process that recycles cellular structures that range in size from proteins to organelles. It's central to many processes of biological repair.

    Research in autophagy is growing very fast, and must be relevant here.

    (BTW, niacin and other antilipolytic agents also induce autophagy.)

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What would life be like . . . ?

What would life be like . . . ?

What if coronary heart disease could be prevented--no eliminated--applying methods that were accessible, easy, and cheap?

What if coronary heart disease and, thereby, angina, heart attack, sudden cardiac death, ventricular tachycardia, heart failure, and the cerebrovascular equivalent, stroke, could be eliminated using readily available tools available to virtually everyone in the U.S.? And, over a year, it cost less than a once-a-week latte at Starbucks?

How would the healthcare landscape change? What would become of hospitals, manufacturers of the billions of dollars of hospital equipment necessary to supply the cardiovascular hospital industry (e.g., stent manufacturers, catheter manufacturers, defibrillator and pacemaker manufacturers, pharmaceutical manufacturers who no longer have to produce the volume of antiplatelet agents, inotropic drugs, antiarrhythmic agents, etc.)?

How would our lives change? What would the end of life look like if people stopped dying of heart attack, sudden cardiac death, congestive heart failure at age 55, 65, or 75, but lived out their lives to die of something unrelated?

What if the solution had little or nothing to do with drugs but evolved from simple nutritional strategies, supplements meant to correct the deficiencies that accompany modern lifestyles, and a few unique strategies targeted towards the genetic predispositions that lead to heart disease?

What if all this were possible at a cost of a few hundred dollars per year?

It would certainly be a cataclysmic change. Hospitals would shrink to a small remnant of their current gargantuan, dozens-per-city presence. The need for hospital staff would be slashed by over half. The rare cardiologist would tend to congenital heart disease sufferers and other unusual forms of heart disease and he or she might have a colleague or two in all of a major city.

Healthcare costs would plummet, no longer having to sustain the enormous cardiovascular healthcare machine of hospitals, staff, industry, and long-term care. Health insurance, private or public, would drop by 50%.

It would free up nearly a trillion dollars that could be redirected towards other pursuits, like schools and research. Extraordinary leaps forward in quality of life and science would emerge, given that magnitude of funding.

It's not as grand a thought experiment as Alan Weisman's The World Without Us, in which he imagines what the world would be like without humans altogether.

How long would it take to recover lost ground and restore Eden to the way it must have gleamed and smelled the day before Adam, or Homo habilis, appeared? Could nature ever obliterate all our traces? How would it undo our monumental cities and public works, and reduce our myriad plastics and toxic synthetics back to benign, basic elements?

But I believe this thought experiment--what would life be like without heart disease because it was eliminated using inexpensive tools-- is more plausible, more likely to occur. In fact, it has already begun to occur.

See those vines growing up the side of the hospital?

Comments (16) -

  • Jenny

    7/29/2009 12:39:12 PM |

    What would life be like without CVD deaths?

    For a while, the way you describe. But as more people lived into their 80s and 90s the rate of dementia would rise dramatically.

    If you visit any dementia facility you will find it is full of normal weight people many of whom are in otherwise "excellent" health--that's what got them to live to 88 or 92.

    But once demented, their lives are tragic. Saddest are those who are just demented enough to be totally confused, but not enough that they are oblivious to their condition. All people with moderate dementia  need round the clock care which is not covered by Medicare unless they have no assets. This depletes the savings of humble people who have worked for decades who are left with nothing to leave their children.  Depending on the cause of their dementia people may need full time care for a decade. Once they have no money they are turned over to the warehousing of nursing homes, many of which are horrendous  where those who are still conscious may pray daily for death.

    Right now one half of those in the 80-100 age group are demented. The humiliation  dementia inflicts on loved ones is so terrible that anyone who has a relative in this condition (and we have two in our family) will pray that they have enough heart disease to take them out before they go through that long, slow degrading decline.

    Many people have unrealistic ideas that they could take care of a loved one with dementia which stem from not having been put face to face with it since the truly demented are usually locked away somewhere.

    Note too that though there are attempts to blame dementia on diabetes, I don't buy it. The rate of dementia has climbed with the climb in lifespan though "senile dementia" has always been the fat of a good portion of those who lived to be old-old.

    The diabetes diagnosed late in life is part of the gradual failing of their organs and often not the same as diabetes diagnosed in the 40s. It may be associated with dementia but it is far from proven that it is causative.

    Beside that, eliminate CVD and the rate of people dying from the prolonged agony of cancer would go up too, because the older people get the more likely they are to develop cancers. Something many people don't know is that chemotherapy administered to older people id prone to cause dementia. It causes mild cognitive problems  in younger people too, but in the old-old it is much more likely to take out their memories.

    I'm all for eliminating the kind of CVD that takes people out young, especially since it is so often linked to genetic abnormalities.  But for those in their 70s and beyond, eliminating CVD might simply be to trade one condition for another far worse.

    No one lives forever.

  • Lucy

    7/29/2009 1:21:40 PM |

    It sure doesn't seem like that will happen anytime soon, at least not here... I spent all day calling around to local docs (including cardiologists) and NO ONE had even heard of advanced lipid testing...  I'm ashamed to say that I work for a large hospital system that wants to be "cutting edge" and all about research yet they have no knowledge of basic preventative care in regards to the leading cause of death in our country?!!

    Is advanced lipid testing really that advanced?

  • JPB

    7/29/2009 3:25:12 PM |

    That is part of my dream, too. But first, people have to have access to correct information, stop being so passive with medical professionals  and then take an active role in establishing and maintaining their own heath.  The real "health" care reform would do everything that you say but would come directly from the people who are receiving so-called medical "care."

    Of course, the vested interests will fight this tooth and nail but it would be tough to stop if our population would finally wake up to the way they are being manipulated!

  • Dr. William Davis

    7/29/2009 4:26:06 PM |

    Hi, Jenny--

    Thanks for your thoughts.

    But I would rather succumb to dementia at age 90 (that I helped delay with vitamin D and other mental-preservation methods) than heart attack at age 59, bypass at age 60, three stents at 63, four more at age 68, living a life of hospital revolving doors. Don't forget about the defibrillator that aborts the ventricular tachycardia that comes from the scar in your left myocardium from the original heart attack.

    Millions of people live this way and have not been told that it doesn't have to be this way. That's what I'm talking about.

  • Dr. William Davis

    7/29/2009 4:28:29 PM |

    Lucy--

    NOT having advanced lipid testing impairs the identification of the causes of heart disease. It is a big step towards better control over heart disease risk. It identifies treatments that often have nothing to do with more need for medication--that's why your doctors don't know about it.

    You probably already know that the bulk of medical "education" does not come from journals or scientific publications, but from the pretty drug representative with dinner invitation in hand waiting in the doctor's waiting room.

  • Anne

    7/29/2009 4:36:15 PM |

    Dear Dr Davis,

    Your mention of congenital heart disease sufferers made me wonder if you could possibly write a blog about how people with congenital heart disease can improve their heart health please.

    Anne

  • Helena

    7/29/2009 5:51:55 PM |

    Dr. Davis

    I am with you! And to be honest – it is actually horrible WRONG that we are not yet there. We (or at least many people) already know how to escape the dreadful C V and D. Why it is not already implemented in every hospital, doctors’ office, and even in education is scary! But most of it has got to do with a short-term money flow, I would guess.

    As boldly as I think we can put most cardiologists out of business I also believe we can eliminate many cancer diseases by natural remedies!

    No one has to believe me, but sometimes we are to do ourselves a favor and listen to those who have the degrees to say and act upon statements. What about these well selected and bold statements:

    John P. Cook M.D. Ph.D. in his book “The Cardiovascular Cure – How to strengthen your self defense against heart attack and stroke” In his book you can read this: “There is magic within all of us. It comes in the shape of a molecule known as nitric oxide.  A substance so powerful that it can actually protect you from heart attack and stroke.  Best of all your body can make it on its own.  Nitric oxide is your body’s best defense against heart disease.  The body is capable of healing itself.  What you do with the magic is up to you.”

    Dr. Louis J. Ignarro; Nobel Prize Laureate in Medicine, 1998; “NO more heart disease – How Nitric Oxide can prevent, even reverse, heart disease and stroke” and you can read this in the book: "You do not have to wait for the rest of the world to see the light--and the drug companies to put new Nitric Oxide-based prescription drugs on the market--in order to take advantage of what Nitric Oxide has to offer.  Even if you have high blood pressure, have suffered a heart attack, or are at high risk...You can beat the odds.  The power to lead an entirely new and healthier life is in your hands.  Carpe Diem--Seize the day!  Start boosting your Nitric Oxide production right now!“

    Dr. Jonathan S. Stamler; Professor of Medicine; Duke University Medical Center - "It [Nitric Oxide] does everything, everywhere. You cannot name a major cellular response or physiological effect in which [Nitric Oxide] is not implicated today. It's involved in complex behavioral changes in the brain, airway relaxation, beating of the heart, dilation of blood vessels, regulation of intestinal movement, function of blood cells, the immune system, even how fingers and arms move.“
            
    What these gentlemen are talking about is Arginine (arginine transforms into Nitric Oxide once in your body). And Arginine has also been found to: “Improve Memory & Cognitive Functions” (J Physiol Pharmacol 1999), and “May inhibit the division and proliferation of cancer cells” (Br J Surg. 1997)

    The list goes on and on… Arginine 5gr or more a day along with Citruline and antioxidants on a daily regularly basis can do all these things and we can at the same time fight cancer and dementia! It is all out there in the nature for us to use!!!

    Thanks again for a wonderful blog – if anyone is interested in learning about different product options they can email me (don’t want to advertise anything here – this is about people, not money) Helena.mathis@hotmail.com.

  • Helena

    7/29/2009 5:52:31 PM |

    Dr. Davis

    I am with you! And to be honest – it is actually horrible WRONG that we are not yet there. We (or at least many people) already know how to escape the dreadful C V and D. Why it is not already implemented in every hospital, doctors’ office, and even in education is scary! But most of it has got to do with a short-term money flow, I would guess.

    As boldly as I think we can put most cardiologists out of business I also believe we can eliminate many cancer diseases by natural remedies!

    No one has to believe me, but sometimes we are to do ourselves a favor and listen to those who have the degrees to say and act upon statements. What about these well selected and bold statements:

    John P. Cook M.D. Ph.D. in his book “The Cardiovascular Cure – How to strengthen your self defense against heart attack and stroke” In his book you can read this: “There is magic within all of us. It comes in the shape of a molecule known as nitric oxide.  A substance so powerful that it can actually protect you from heart attack and stroke.  Best of all your body can make it on its own.  Nitric oxide is your body’s best defense against heart disease.  The body is capable of healing itself.  What you do with the magic is up to you.”

    Dr. Louis J. Ignarro; Nobel Prize Laureate in Medicine, 1998; “NO more heart disease – How Nitric Oxide can prevent, even reverse, heart disease and stroke” and you can read this in the book: "You do not have to wait for the rest of the world to see the light--and the drug companies to put new Nitric Oxide-based prescription drugs on the market--in order to take advantage of what Nitric Oxide has to offer.  Even if you have high blood pressure, have suffered a heart attack, or are at high risk...You can beat the odds.  The power to lead an entirely new and healthier life is in your hands.  Carpe Diem--Seize the day!  Start boosting your Nitric Oxide production right now!“

    Dr. Jonathan S. Stamler; Professor of Medicine; Duke University Medical Center - "It [Nitric Oxide] does everything, everywhere. You cannot name a major cellular response or physiological effect in which [Nitric Oxide] is not implicated today. It's involved in complex behavioral changes in the brain, airway relaxation, beating of the heart, dilation of blood vessels, regulation of intestinal movement, function of blood cells, the immune system, even how fingers and arms move.“
            
    What these gentlemen are talking about is Arginine (arginine transforms into Nitric Oxide once in your body). And Arginine has also been found to: “Improve Memory & Cognitive Functions” (J Physiol Pharmacol 1999), and “May inhibit the division and proliferation of cancer cells” (Br J Surg. 1997)

    The list goes on and on… Arginine 5gr or more a day along with Citruline and antioxidants on a daily regularly basis can do all these things and we can at the same time fight cancer and dementia! It is all out there in the nature for us to use!!!

    Thanks again for a wonderful blog – if anyone is interested in learning about different product options they can email me (don’t want to advertise anything here – this is about people, not money) Helena.mathis@hotmail.com.

  • Tom

    7/29/2009 5:57:35 PM |

    Alzheimer's and heart disease are thought to be connected -- they may both be the result of arterosclerosis.

    So a world with fewer CHD victims might not be a world with more dementia patients.

  • trinkwasser

    7/29/2009 6:41:32 PM |

    Yes I see both your points. I strongly suspect I am going to die significantly younger than others in my family thanks to the clueless doctors who decided not to diagnose my diabetes, and worse, put me on a high carb low fat diet to "cure" my appalling lipids.

    On the one hand going quick of a heart attack while in my prime would be far preferable to what happened to one of my mother's friends: after a quad bypass she gradually declined from being a fit active sociable person to someone who was blind, deaf and incapable but whose heart would NOT stop and give her the release she prayed for. Once you get into that state they can warehouse you for years.

  • Roger

    7/30/2009 3:10:19 AM |

    My mom was one who met Jenny's tragic fate.  She did Pritikin and McDougall for years, decades actually.  Though she was a lawyer, played piano and read constantly, Alzheimer's (or a similar dementia) overtook her in her 70s.  She spent several years with caregivers in her home, and then six long years in a deluxe nursing home, burning up all the assets she had saved her entire life.  All we could do was watch.

    I believe the low-fat diet she followed wasn't what her brain needed.  She was probably chronically starved for EFAs, especially Omega-3.  But we didn't know what we know now, so we couldn't help.  Of course, I can't know for sure this was the causative factor...maybe this is just my defense mechanism.  But I think Dr. Davis's point is that addressing CVD in no way excludes also addressing dementia.  There's tons of exciting research being done.  Plenty of folks make it to the very end with all their faculties intact.  Why?

  • Tara

    7/30/2009 3:15:35 PM |

    Dr. Davis,

    What is your opinion on genetic testing and it's potential effect on the treatment of both CVD and (since it's been mentioned in this discussion) dementia?   I know both my ApoE and KIF6, and find it all very fascinating.  I am a 4/3 and a noncarrier for the risky form of KIF6.  I do think there are some potential ethical concerns with genetic testing, but I do see benefits as well.  For instance, supposedly my KIF6 result means that I would likely not benefit from a statin.  So, it's extra leverage in my mind when discussing treatment options with my cardiologist.

  • trinkwasser

    7/30/2009 3:29:34 PM |

    "I believe the low-fat diet she followed wasn't what her brain needed. She was probably chronically starved for EFAs, especially Omega-3"

    My God, that's an excellent point! Nursing home/hospital food is almost always high carb low fat (and cheap)

  • Miki Ben Dor

    7/30/2009 9:41:55 PM |

    Dr. Davis
    From what I have learned here and in other like minded blogs (Eads, Stephan, Hyperlipid, BG and others)it seem that the whole metabolic syndrome can be prevented + autoimmune diseases and probably many cancers. This has the potential of really emptying out the hospitals and leaving maily the preventative medicine heroes like yourself and Eads in the front where you belong
    I have recently started a blog in Israel, translating to Hebrew some of your (and  the other's) posts. The spreading of ideas resemble sometimes the spread of epidemics. It picks up suddenly so lets be optimistic!
    keep up the good work!
    Miki Ben Dor http//

  • DIB

    8/6/2009 4:31:53 AM |

    Dr. Davis,

    Life without CVD is not something that can be dreamed about, but rather something that existed in the recent past.  I have heard stories from MD's who served in the US military during the Korean and Vietnamese wars, and while over there, and in Japan, during those years, were asked by local doctors to call them when the military MD was treating a patient (usually American) for a heart attack or having a heart problem, because they had never or very infrequently seen those kinds of problems in their practices, and wanted to see what it was all about.  So, some parts of the world escaped CVD problems already!

    DIB

  • Dr. William Davis

    8/6/2009 12:18:28 PM |

    Hi, DIB--

    Excellent point!

    I agree: Many lessons are being RE-learned.

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