Track Your Plaque success story blows it

Joe was a Track Your Plaque Success Story. With a starting heart scan score of 278, he dropped it 12 months later to 264, a 5% reduction. Though not a huge reduction, Joe's risk for a heart attack or other coronary event was virtually zero. I was very proud of Joe.

Among the culprit lipoprotein patterns that caused Joe's plaque was lipoprotein(a), or Lp(a). Niacin was therefore crucial to his program. It was among the principal reasons he dropped his heart scan score and reduced his risk for heart attack so dramatically.

Since he retired, Joe has been freewheeling around the country, traveling and having a great time. He consequently stopped thinking about his heart disease and Lp(a). He also tired of the occasional hot flushes he'd experienced with niacin. Though the flushes were promptly aborted by drinking two glasses of water, he simply didn't want to be bothered.

So when Joe saw this interesting and tantalizing "flush-free niacin" on the store shelf, he grabbed it.

Joe came back to the office. His blood pressure was 190/94, so high that he was having occasional chest pains from it (which can happen when something called "left ventricular diastolic dysfunction" develops from hypertension). His lipoprotein patterns were terrible, including a big upward jump in Lp(a) and drop in HDL. So I asked him to have another heart scan right away: Score 371, a 40% increase. In other words, his program went down the toilet.

Why?

Simple: Flush-free niacin. I've said it before (No flush = No effect and No flush niacin kills) and I'll say it again:

Flush-free or No-flush niacin is a complete, unadulterated, completely ineffective SCAM.

Flush-free or no-flush niacin is not a substitute for niacin. Joe is yet another example of how dangerous this scam can be. It turned one of our great success stories into a failure.

Please, please, please do not fall for this misleading and potentially dangerous scam product. While the product itself is not intrinsically dangerous, it denies you the benefits of the real thing: niacin.

Thankfully, the mistake in Joe's program was caught before a heart attack or other catastrophe. He did manage to pass a stress test, though with a flagrantly out-of-control blood pressure response. We'll get him back on track--but with niacin, the real thing.

Comments (3) -

  • Anne

    7/17/2008 12:38:00 AM |

    I am not on niacin, but it is a possibility in my future. Thanks for the reminder.

    Hope that Joe gets back on track, feels better and numbers improve.

  • Anonymous

    7/19/2008 5:16:00 PM |

    This may be a little off the subject, but what do you recommend to patients who can't take niacin?

    For the majority of people, the only side effect is a minor flushing, and when I tried Niacin/Niaspan, the flushing was noticeable, but not a big deal.

    But I also had heart palpitations, fatigue, seemingly worsening asthma, and difficulty sleeping, and had to stop it. Heart palpitations was the one my doctor was concerned about.

    Maybe one day you can discuss alternatives that you recommend for folks who can't take niacin, for raising HDL?

  • Anonymous

    7/20/2008 10:15:00 PM |

    Dr,
    I am glad your blogged about this but for my husband, he gets some of those side effects like that other poster just mentioned. Anxiety, heart racing, weird feeling. So he stopped the "slo niacin" for now.
    Any reply is appreciated.

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Don't believe the negative press on fish oil

Don't believe the negative press on fish oil



A British Medical Journal study released in March, 2006 has prompted a media flurry of reports on the worthlessness of fish oil. (Hooper L, Thompson RL, Harrison RA et al. Risks and benefits of omega 3 fats for mortality, cardiovascular disease, and cancer: a systematic review. BMJ March,2006)

Don't believe it for a second.

First of all, the study was a re-analysis of the existing published scientific literature. It was not a new study. It included a wild conglomeration of different clinical observations, as the studies examining fish oil over the years have been extraordinarily heterogeneous--in populations examined, omega-3 supplement (e.g., fish vs. capsule), period of observation, endpoints measured.

The results were skewed by inclusion of a moderate-sized British study by Burr et al in men with angina. In this study, no benefit was demonstrated and, in fact, a negative effect--more heart attack and death--was observed with fish oil. This was not news, since the study was published in 2003. It's results have been a mystery to everyone, since its unexpected negative result for fish oil was so starkly different from virtually every other study that preceded it (suggesting a study flaw or statistical fluke).

Nonetheless, the Burr study served to throw off the overall analysis. It diluted the dramatic and persuasive outcome of the GISSI-Prevenzione Study of 11,000 people in which a 28% reduction in heart attack and 45% reduction in cardiovascular death was observed. Note that the substantial numbers of the GISSI make the study's outcome nearly unassailable.

Another important fact: fish oil is among the most powerful tools available to correct elevated triglycerides. Drops of 50% are common. Recall that triglycerides are a necessary ingredient to create the nasty LDL, as well as VLDL, Intermediate-density lipoprotein, and an undesirable shift from large to ineffective small HDL. Reducing triglycerides is therefore crucial for your plaque control program.

This re-analysis serves to prove nothing. Such analyses can only pose questions for further study in a real study like GISSI: a randomized (random participant assignment), controlled (treatment vs. placebo or other treatment) study.

The weight of evidence remains heavily in favor of fish oil, not only as helpful, but fabulously beneficial, particularly for anyone aiming to reduce coronary plaque.
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Wheat Belly coming to bookstores!

Wheat Belly coming to bookstores!

Anyone following the conversations on these pages know that I have some very serious concerns about this thing being sold to us called "wheat"--cause it ain't wheat! It is the result of incredible genetics shenanigans inflicted on this plant, mostly in the name of increased yield per acre.



I now classify wheat as "Public Enemy #1," the prime nutritional culprit underlying obesity, heart disease, "cholesterol" abnormalities, hypertension, arthritis, psychiatric illness, and on and on. Once you read the full story, I believe that you will agree: Modern Triticum aestivum, the plant that now serves as the source for virtually all the wheat flour products now consumed--organic, whole grain, multigrain, sprouted . . . it makes no difference--does not belong in the human diet. So many people, searching for solutions for their fatigue, weight gain, leg edema, incurable rashes, joint pain, etc., will find their answers here.

Wheat Belly: Lose the wheat, lose the weight and find your path back to health will be on bookstore shelves including Barnes and Noble August 30, 2011 or is available for preorder here at Amazon. Wheat Belly will also be available as a downloadable Kindle book and as unabridged audio CDs.

You can also follow the Wheat Belly conversations on my Wheat Belly Blog. One of my recent posts discusses the herbicide-resistant semi-dwarf wheat strain, Clearfield, that is now making its way to more and more supermarket shelves.

You'll also find more conversation on the Wheat Belly Facebook pages.

Comments (18) -

  • Jana Miller

    7/31/2011 5:47:19 PM |

    Congratulations...thanks for all you do to educate and inform us about wheat!!
    all the best,
    jana

  • BJ

    7/31/2011 5:55:00 PM |

    The date of the book arrival must be incorrect?  2001?
    I am anxious to read this one!

  • Lori

    7/31/2011 6:05:42 PM |

    I've pre-ordered Wheat Belly and look forward to reading it.

    I'm enjoying my second summer free of hay fever--coincidentally, the first summer was right after I eliminated wheat from my diet. Hurray!

  • Princess Dieter

    7/31/2011 6:39:26 PM |

    Will it be a Nook book? I love my Nook! And I've got Mercola's No Grain diet, some Primal/Paleo books on there already. Would love to have yours, too. Thanks.

  • Princess Dieter

    7/31/2011 6:40:47 PM |

    OMG, I just read Lori's comment, and realize that I've been less asthmatic/allergenic this summer since ditching wheat/gluten. I've been able to scale back (stop Nasonex and cut back on inhaled steroid dosage, even) .  August-September is the worse, runny-nose-wise, so I'll get to observe and see. Hm.

  • Diana

    8/1/2011 12:34:08 AM |

    Congrats on the book! Can't wait to read it!
    Continuing on a comment above, I too have had no seasonal allergies since doing a diet which is wheat-free. Have you ever covered this topic in your blog, or could you in the future?

  • Might-o'chondri-AL

    8/1/2011 9:52:09 AM |

    7 times Sunday/Monday tried to get  just 2 sentence post about ApoE4  in previous thread and got "Server Error", so testing again in this tread ... this lousy server did this before with me.

  • Might-o'chondri-AL

    8/1/2011 10:04:44 AM |

    Anyone still checking this thread want me to continue with some ApoE4 comments here ? I went back to try previous thread and still got "server error" there. I  ask for interest because I myself don't always follow  new thread comments section  - and maybe those with ApoE4 interest are not reading here now.

  • Might-o'chondri-AL

    8/1/2011 5:39:19 PM |

    Just tried to use "reply" box of  Dr. K.'s comment on previous ApoE4 thread  to contribute and got "Server Error";
    let's see if I am still welcomed on this thread by the server....

  • Melinda

    8/1/2011 8:13:42 PM |

    Might-o'chondri-al,

    Yes, I would be interested in your replies about ApoE4.  I always read your comments around the web and like many, I wish you had your own blog so I wouldn't miss any of your output.

  • Might-o'chonri-AL

    8/2/2011 12:57:19 AM |

    Hi Melinda,
    Please copy and post this in previous thread for ApoE4 ... .
    Continuation about ApoE4:
    % of ApoE4 messes dynamic inside tissue cell so that ApoB turns to use Scavenger Receptors to try to start cascade which gets signal transducer (Specificity Protein 1) to up-regulate the cell membrane transporter protein ( ABCA1, ATP binding cassette transporter A1) that puts excess cholesterol out from that cell.   I believe this is where Doc Davis' stated ApoB irregularities  add to the problem with ApoE4 (since normal human ApoE3  works all by itself to get that signal transducer to bind to ABCA1 to work shucking cholesterol) . When cholesterol gets to build up inside the cell the large LDL can acetylate and form  excessive "droplets" in that cell's cytoplasm; while the small LDL can oxidize from CuSO4- and load up inside that cell's lysosome.

    Meanwhile % of  ApoE4 doesn't just dock with tissue cell LDL receptors and so the macrophage scavenger receptors pick up too much cholesterol laden ApoB/ApoE lipo-protein carrier molecules. Once in the macrophage the same problem of oxidized LDL piling up  in lysosome and acetylated LDL burdening cytoplasm occurs; and for that matter, in macrophages,  it is down to ApoB to get  the signal transducer going if any cholesterol is to be put out by cell membrane transporter protein ABCA1.  This is the recipe for  risky pro-atherogenic  "foam cell" formation; while the individual genetics of ApoE, ApoB, assorted receptor types, signal transducer and transport protein all make it hard to predict how ApoE4 plays out.

    Dr. Kruse broaches ApoE4 in alzheimers and this is in large part because ApoE4 causes the brain neurons to  get less than optimal cholesterol from the brain's astrocytes. It is ApoA1 working in HDL complex that controls the astrocyte cholesterol balance and when there is inflammation there is a risk of ApoA1 mis-folding to  foster amyloid aggregations.  Low intact ApoA1 and ApoE4 together increase the risk factor for cognitive problems and dementia several fold.

    Diabetics with ApoE4 have that % of ApoE4 as an  additional  limitation;  however,  irregardless of  the ApoE iso-form diabetic dementia risk arises from their glucose loads impairing kidney tubules, and thus fostering the uremic environment that stymies ApoA1 bio-synthesis. The normal role of ApoA1 is to bind to the transport protein which secures cholesterol into a safe bond with HDL; so low ApoA1 from any factor will  challenge the brain neuron over time. I suggest there are individuals whose age impaired kidneys contribute to senile dementia from impairing ApoA1 levels being made and also possibly speeding up the normal 4-6 days kidney elimination of ApoA1 ; and  so Patri's comment on limitation of high protein intake is relevant due to it's demand on aging  kidneys.

  • Dr. William Davis

    8/2/2011 1:58:16 AM |

    Oooops! Too many zeros and too few ones!
    Yes, indeed, 2011. Thanks, BJ.

  • Dr. William Davis

    8/2/2011 1:59:11 AM |

    Hi, Lori-
    I personally experienced the very same effect.
    I remember days in which my eyes were swollen shut, sinuses achingly closed, wheezing. All now a distant memory!

  • Dr. William Davis

    8/2/2011 2:00:39 AM |

    Yes, great idea, Diana. I'll cover that topic, though likely more appropriate for the Wheat Belly Blog.
    I will likely mirror this post in both blogs. It affects a LOT of people.

  • Dr. William Davis

    8/2/2011 2:02:19 AM |

    Hi, Might--
    Sorry for all the posting struggles. I'm still working with working out the kinks.
    The changes here are occuring with some back room changes in database software, etc., that is making for more than the usual headaches.
    Please don't give up in frustration. Your comments are truly valued.

  • MJ Klein

    8/2/2011 2:07:31 AM |

    is this primarily a US problem?

  • Might-o'chonri-AL

    8/2/2011 5:25:41 AM |

    Hi MJ,
    ApoE4 =  14-19% Germans & Finns and  7-12% Italians & French
    ApoE3 = +/- 60% of people
    ApoE2 = 3-4% Japanese, Finns & Nigerians and 2-4 % Mexican Americans & American Indians

  • Stella

    11/11/2011 10:55:36 AM |

    Just wondered if you were aware that for several days now (all this week, for sure) Amazon UK has been displaying the following message on the Wheat Belly page:

    "Item Under Review
    This product is not currently offered by Amazon.co.uk because a customer recently told us that the item he or she received was not as described.
    We are working to resolve this as quickly as possible. In the meantime, you may still find this product available from other sellers on this page."

    Maybe they were expecting bagel recipes? There is no explanation, and the three accompanying reader reviews are all 5*

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