I've taken prescription Niaspan for over an year and a half.  Several times I've had an unintended "untoward" reaction, more than a blush, more than a flush... more like a niacin storm!  Each time I've learned something new, however.  Yes, hydration is very important.  There are certain foods and drugs which apparently dam up the same metabolic pathway as niacin, and can cause a pretty nasty reaction.  Among these, at least for me, are certain long acting antibiotics (Zithromax), spicy chai tea, pepperoni (not supposed to go there anyway!) and very spicy foods, if taken near the time of Niaspan dosing.  I was advised by my Dr. that Benadryl syrup would help to shorten the duration of the "storm".  Mostly it's a case of dietary management and timing of dosage.  The good done by niacin certainly still outweighs the occasional bad side effects!

Another comment about niacin from this long-time niacin user, maybe folks will find it useful...
Dr. Davis's advice to hydrate heavily to prevent/reduce flushing is, alas, not completely effective. One can easily prove this for oneself. The next time you experience a big flush, consume as much water as you are able, and see if the flush quickly resides..does it?  No. Hydration is certainly great advice, I'm not knocking it, but as a flush reduction strategy, it isn't enough. One commentor here mentioned quercetin.  It seems some recent research on certain flavonoids (quercetin, luteolin) have produced good results,better than aspirin, which was mentioned in this thread.  One needs to experiment and see if supplements such as these do help, taken maybe 30-45 minutes before the niacin dose. I have some other comments on niacin strategies I've hardly seen mentioned anywhere, but I'll wait until (1) I see my posts are approved (I'm new here), and (2) that people are interested. Let's see if there is any feedback. Regards, Jim

I've been taking niacin  2 times daily for 6 months and dropped my cholestral from 240 to 162.  Can I go back to once daily?

I have seen some research papers that report that NIACIN, Nicotinamide and/or SAMe ( maybe also other methyl donors such as TMG ) can cause Parkinson's disease. I wonder if niacin can be converted to Nicotinamide in the body. Please see their abstracts and URLs below. Thank you.



Niacin Metabolism and Parkinson’s Disease

Tetsuhito FUKUSHIMA1)
1) Department of Hygiene & Preventive Medicine, Fukushima Medical University School of Medicine
Abstract
Epidemiological surveys suggest an important role for niacin in the causes of Parkinson’s disease, in that niacin deficiency, the nutritional condition that causes pellagra, appears to protect against Parkinson’s disease. Absorbed niacin is used in the synthesis of nicotinamide adenine dinucleotide (NAD) in the body, and in the metabolic process NAD releases nicotinamide by poly(ADP-ribosyl)ation, the activation of which has been reported to mediate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson’s disease. Recently nicotinamide N-methyltransferase (EC2.1.1.1) activity has been discovered in the human brain, and the released nicotinamide may be methylated to 1-methylnicotinamide (MNA), via this enzyme, in the brain. A deficiency in mitochondrial NADH:ubiquinone oxidoreductase (complex I) activity is believed to be a critical factor in the development of Parkinson’s disease. MNA has been found to destroy several subunits of cerebral complex I, leading to the suggestion that MNA is concerned in the pathogenesis of Parkinson’s disease. Based on these findings, it is hypothesized that niacin is a causal substance in the development of Parkinson’s disease through the following processes: NAD produced from niacin releases nicotinamide via poly(ADP-ribosyl)ation, activated by the hydroxyl radical. Released excess nicotinamide is methylated to MNA in the cytoplasm, and superoxides formed by MNA via complex I destroy complex I subunits directly, or indirectly via mitochondrial DNA damage. Hereditary or environmental factors may cause acceleration of this cycle, resulting in neuronal death.

Key words:
nicotinamide N-methyltransferase, 1-methylnicotinamide, poly(ADP-ribosyl)ation, mitochondria, complex I

Pasted from http://www.jstage.jst.go.jp/article/ehpm/10/1/10_3/_article


Parkinson's disease: the first common neurological disease due to auto-intoxication?
A.C. Williams1, L.S. Cartwright2 and D.B. Ramsden2
From the Divisions of 1Neurosciences and 2Medical Sciences, University of Birmingham, Birmingham, UK
 
Parkinson's disease may be a disease of autointoxication. N-methylated pyridines (e.g. MPP+) are well-established dopaminergic toxins, and the xenobiotic enzyme nicotinamide N-methyltransferase (NNMT) can convert pyridines such as 4-phenylpyridine into MPP+, using S-adenosyl methionine (SAM) as the methyl donor. NNMT has recently been shown to be present in the human brain, a necessity for neurotoxicity, because charged compounds cannot cross the blood-brain barrier. Moreover, it is present in increased concentration in parkinsonian brain. This increase may be part genetic predisposition, and part induction, by excessive exposure to its substrates (particularly nicotinamide) or stress. Elevated enzymic activity would increase MPP+-like compounds such as N-methyl nicotinamide at the same time as decreasing intraneuronal nicotinamide, a neuroprotectant at several levels, creating multiple hits, because Complex 1 would be poisoned and be starved of its major substrate NADH. Developing xenobiotic enzyme inhibitors of NNMT for individuals, or dietary modification for the whole population, could be an important change in thinking on primary and secondary prevention.


Pasted from http://qjmed.oxfordjournals.org/cgi/content/full/98/3/215

see also
http://www.springerlink.com/content/d5wurtwylvpcy04q/


But,on the contrary,the paper below seems to suggest that niacin protects from Parkinson's.

Title: Does diet protect against Parkinson's disease? Part 4 – vitamins and minerals
Author(s): Isabella Brown
Journal: Nutrition & Food Science
ISSN: 0034-6659
Year: 2004 Volume: 34 Issue: 5 Page: 198 - 203
DOI: 10.1108/00346650410560343
Publisher: Emerald Group Publishing Limited
Abstract: This paper is the fourth in a series on Parkinson's disease and diet and investigates the role which antioxidant vitamins A and C, niacin and selenium may have on the incidence of the disease. Oxidative stress is believed to be a key factor in the development of PD and all of these have a role in preventing oxidative stress mediated cell damage. Dietary information was obtained via questionnaires. Vitamin C was found to reduce the risk of PD by 40 per cent in one study, although this was not supported by other studies. Niacin was associated with an at least 70 per cent reduced risk of PD incidence in a number of studies. No evidence was found to support a role for vitamin A or selenium. There is a need for further research to support or disprove the roles of these antioxidant vitamins within the aetiology of PD.
Keywords: Diet, Diseases, Lifestyles, Vitamins
Article Type: Research paper
Article URL: http://www.emeraldinsight.com/10.1108/00346650410560343

One of the ways to deal with coronary heart disease is by eating healthy there is no magical pill in this case, it's just as simple as that.

Have a serious discussion and press for confident answers if you find your doctor reflexively telling you that the wart on your thumb should be blamed on niacin.

The proper diet is essential for diabetic treatment. It helps magically in patients suffering from diabetes. It provides relief from symptoms and various complications in diabetics. Many diabetic patients can control their blood glucose by losing weight and that is possible only be proper diet.

Regards
Alexa

If you're going to base your diet on the bible, then you shouldn't be eating pork (Leviticus 11:7), and you should eat plenty of locusts and crickets (Leviticus 11:22)

Oooh, wait'll the God-deniers get a load of this one.

Actually, I've wondered about the proper interpretation of passages like those mentioned, and this post is helpful for me.

I appreciate this & putting the verses into context - but was human excrement to be used as content in the bread, or the fuel source to bake it?

I'm pretty sure the dung was not to go into the bread, it was to be used as fuel for the fire over which the bread was baked. But your point still holds very well. They also omit the lying on your side for 390 days. If eating Ezekiel bread is so healthy, so must be lying on your side for over a year.

I prefer to "kill the fattened calf."

LOL

Dung was probably not an ingredient, but the fuel used to cook the bread.  (Still pretty unsavory, though.)

1) All religion is poetry...

-- Paul Tillich

2) I have a huntch that, uh, folks from a couple thousand years ago, uh, never heard of macronutrients, glucose, insulin, etc.

3) Peace

For those who are interested in the Bible's statements on food, here's a link to a brief overview of kosher laws:

http://www.kashrut.com/articles/soul_food/

Combining a lesson in both religion and medicine, Love It!!

I agree with you, Dr. Davis, that religious issues are very important to many people concerned about dieting. And it is important to discuss them, even though some people think that religious issues should not be part of any discussion related to diet.

In fact, a lot of people who think  about diet issues from a scientific standpoint tend to think that religiosity is a product of pure stupidity. This post and the comments in response to it illustrate what I am talking about:

http://healthcorrelator.blogspot.com/2010/05/atheism-is-recent-neolithic-invention.html

Waiting for my local library to get a copy of Pandora's Seed by Spencer Wells. In it, he examines the unforeseen costs of farming, which began to transform society 10,000 years ago (using a scientific timescale), such as diabetes and obesity.

Definitely one of man's worst inventions.

Interesting fact:  The Catholic church will not use anything other than wheat to make the wafers for the Eucharist.  If you have wheat intolerance, you can request a low-gluten wafer.  But a non-wheat wafer will never be used as part of that sacrament, no matter how badly one might react to wheat.

I think that stance is a bit much, but I am not a devout Catholic.

Dr. D.
As the Brits say; you are on a losing wicket.

No person of religion will be pursued to move from the crowd. That is why they follow.

Great post! I've never understood how people can take the Bible literally. As someone mentioned in the comments, it's mainly poetry, and it describes a frame of reference and customs of thousands of years ago. Would be very weird to apply all that literally to our high-tech society.

I looked the Bible fragment up in Dutch. It says he has to bake it on human dung (i.e. using the dung as fuel). The fun thing is that a couple of verses later Ezechiel complains and says he has never eaten anything impure in his life and then God gives in and says, 'OK then, you can use cattle dung instead of human dung.'

Sounds to me like the beginning work on "fecal transplant".

But, here's the question: do you think the Ezekiel Bread is worth eating for health reasons?

Other translations have the dung as a source of fuel.  
As much fat as I eat, you'd probably have to put a wick in it.
I don't think that would give it a nice smoke flavor or anything.

I think some of these comments are missing the point. Whether the dung was used as fuel or incorporated into the recipe makes little difference to the interpretive thrust of the passage. According to Mosaic ceremonial law (which was typological, not perpetual), excrement was to be covered with dirt. You don't touch it, and you certainly don't cook with it. The point is that the bread was polluted, and this served as a typological symbol of Israel's pollution and rejection. Israel, the elect and "clean" nation, has become filthy.

God didn't make Ezekiel write this stuff down so we could whip up a great recipe 2400 years later. And by the way, the same goes for the book of Daniel. Just because Daniel and his buddies ate nothing but vegetables and water for ten days doesn't mean that vegetarianism is the best diet. That's not even close to the original intent of the passage. Yet I see these kinds of non-contextual claims all the time. It saddens me when I see fellow Christians using the Bible this way.

FYI: The "Wheat and the Bible" article can be accessed in its entirety on my website here: http://www.reforminghealth.com/Wheat_and_the_Bible.pdf

David

Thanks, David.

For anyone else interested, David's article provides a very nice overview of the broader topic of Wheat and the Bible.

Dr. Davis, I appreciate your courage in tackling this difficult subject. Dr. Kurt Harris has also discussed the fact that even traditional methods of processing wheat do not eliminate all of its negative qualities: http://www.paleonu.com/panu-weblog/2009/12/28/avoid-poison-or-neutralize-it.html.

Religious concerns are undoubtedly one of the trickiest issues that biologically appropriate diets raise. Everyone on the planet is not going to abandon what they see as their religion principles for health reasons, so I try to meet people where they're at. For those Christians who tell me that wheat must be healthy because it's in the New Testament and the Levitical diet, I say, sure, the Levitical diet is older and healthier than the SAD of today, but there was an even earlier diet in the Bible that's even healthier. It's composed of God-made foods instead of man-made foods. It usually occurs to them that this is the diet of wild foods available at the time of humanity's creation, which I also refer to as the "Garden of Eden diet", which was free of wheat bread, even unleavened, and certainly wouldn't contain any pizza, pasta or processed breakfast cereal. This doesn't always convince people, but it rarely fails to give them pause.

Plus, in Genesis 3:17-19, bread is part of a curse, not a blessing. So wheat could be regarded as a blessing compared to starvation, but a curse or penance compared to the original Biblical foods of the Creator's making.

Also, at times in the Bible, suffering is treated as an opportunity for penance or purification. It doesn't mean the bad stuff that causes the suffering (ie wheat) is "good" in and of itself. Perhaps this could be a way to explain Jesus' direction to eat bread in remembrance of Him? I generally avoid this subject as potentially too touchy, so I'm curious for input from wheat-avoiding Christians on how they deal with this.

On top of all the above, bread is no longer necessary for survival in wealthy modern cultures, like it may have been in some of the regions and times covered by the Bible. So the contexts are very different.

Hope this helps.

Paleo Phil,

As a wheat-avoiding Christian, I deal with this issue by actually trying to return the focus to the intent of the Biblical text(s). Was it the biblical author's intent to communicate wheat/grain as perpetually appropriate and required foods for all time (unlikely), or was it rather simply that the biblical narrative existed within an agricultural context and was thus accommodated to those times? I think the latter option is the reasonable one.

In the biblical account, all of creation is said to be "good" (as opposed to Gnosticism, which says that matter is intrinsically evil) but I think it is a mistake to take this as synonymous with "harmless," and it is important to remember that despite being "good," elements within creation can be either appropriate or inappropriate depending on the use and context. Plant toxins are "good" in the creational sense in that they make for a balanced and workable ecosystem, but are relatively "bad" for the unwary animal that eats them. The wheat/grain issue is no different. Grains might be creationally good and play an important role somewhere in the broader order of things, but this doesn't mean they're harmless if the circumstances are right (e.g. genetic modification, improper preparation methods, etc., etc.).

Appealing to the "Garden of Eden diet" might work for some Christians, but I think there's a deeper problem going on. Too many modern Christians see the Bible as a sort of "prescription" for what they should or should not eat. For instance, the Levitical diet (clean vs unclean foods) is often pointed to as the ultimate "healthy diet." However, the health aspects had nothing to do with the actual declared purpose of the restrictions. The diet was purely typological and temporary, and any health benefits were merely coincidental side-benefits. These typological requirements have had an antitypical fulfillment, however, so the diet should have no bearing on anyone today.

Likewise, many Christians point to the supposedly vegetarian diet in Genesis as the "original" diet that mankind was created for. But again, this misses the point of the author's literary intent. What was going on in the Genesis creation account? Was Moses telling us how to eat, or was he telling us something completely different? Most Christians are clueless here. As it turns out, the creation story has nothing to do with scientific explanations or dietary prescriptions. It was written in an ancient Near Eastern (ANE) context where creation myths abounded, and Moses was contrasting the Hebrew God with the surrounding deities of the ancient world. The account is not relating scientific facts, but is rather a literary polemic written to combat other ANE pagan religions point for point. The God of Israel is not like Ptah, or Shu, or Marduk, or Baal. The Genesis account powerfully overturns the Enuma Elish and other ANE creation stories. That was its historical intent.

Unless one is familiar with ANE culture, many of the subtleties within the Genesis account will not make sense, and you will end up with an interpretive disaster, like Young-Earth Creationism or Vegetarianism, for instance. The Bible does say that God created, but it does not tell us how He created. This is nowhere near the intent of the original author.

(Continued)

As I read the chapter, it looks more like Ezekiel is instructed to act in a symbolic manner.  He is instructed to symbolically lay seige to a model of Jerusalem that is drawn or built on a tile--even building miniature seige engines. In essence, the call to moral behavior in the book is a "seige" against the transgressions done within the city.  Thus, the "bread" is also to be made and eaten as a symbol.  The context is fairly plain.  Nowhere is there any statement that Israel, or even just Jerusalem, is to make or eat the stuff.  Ezekiel is told to bake and eat the bread "in their sight" or "in the sight of the people" and then tell anyone who sees him that this is the level of wretchedness they will be reduced to, I presume because of their faithlessness and obstinacy after many warnings, given the general context of the Book of Ezekiel.

Thus, "Ezekiel bread" is actually a symbol of the wrath of God against the obstinately faithless and not a "recipe" for what God wants a faithful believer to eat daily.