How did Cureality get its start?




In the Cureality program, we embrace information and strategies that empower you in health without drugs, without hospitals, without procedures. We convert your doctor from director of healthcare to your assistant in health. He or she is there when you need help, but you largely direct your own health future.

How did we gain the know-how, information, tools, even chutzpah to take on such an ambitious project?


It started around 10 years ago with the awkwardly named Track Your Plaque program. In fact, some of the current followers of the Cureality program are former Track Your Plaque members, having learned of the wonderful list of strategies that can be adopted to gain better control over, even reverse, coronary atherosclerotic plaque and risk for heart attack. They also learned that something special happens when you engage with other people with similar interests, all sharing ideas, insights, and resources to get the self-directed health job done. Over time, what started out as simply a source of better information for coronary health evolved into a self-directed coronary disease management program. We never set out to create something as wildly ambitious as a do-it-yourself-at-home coronary disease risk management program, but that is how it inadvertently turned out.

How we went from Information Provider to Health Empowerment Program

So we never intended to take on something so seemingly impossible as managing coronary risk on your own. But, because we armed people with such empowering, profound insights into better ways to manage their heart disease risk beyond “don’t smoke, cut saturated fat, be active, and take a statin drug”—the typical advice offered by doctors—they returned after an interaction with their doctors disappointed: doctors often declared such strategies unnecessary, or the doctor didn’t understand them—even when there were clear-cut clinical data already available to support their use. In other words, the patients—everyday people, not experts—knew more than their doctors. 

This flip-flop in the balance of knowledge made for some very interesting stories, like “Harold” (not his real name) who, having survived a heart attack and received a stent, was told by his doctor to cut his fat intake, eat more whole grains, exercise, take aspirin and a beta blocker drug, and reduce his cholesterol values with a statin drug. Upon learning all the additional information from the Track Your Plaque program, Harold returned to his doctor and asked “I’m not so ready to just go along with this idea of ‘reducing cholesterol’ to address heart disease risk. Because my goal is to gain as much control over coronary disease as possible, maybe even reverse it, I’d like to address some additional issues that I believe may be important. I’d like to have my advanced lipoproteins drawn to measure the proportion of small LDL particles I have, whether I have lipoprotein(a), an omega-3 fatty acid index and 25-hydroxy vitamin D level, and a thyroid assessment. Oh, and I believe I should also have an assessment of my inflammation status, perhaps a c-reactive protein and phospholipase A2, and my blood sugar status measured with a fasting glucose, insulin, and hemoglobin A1c.” Harold’s doctor was dumbfounded and speechless. Rather than reveal his ignorance, his doctor advised Harold that none of that was necessary, sending him on his way and telling him that he was fine.

But this left Harold with a sour taste in his mouth, having engaged in many online discussions with people who had followed conventional advice that resulted in more heart attack, more heart procedures—the conventional answers simply did not work. He also discussed his situation with people who had successfully obtained the additional information he sought, added it to their program and enjoyed dramatically improved health, including freedom from more heart attacks, heart symptoms, and heart procedures, as well as improved overall health. So Harold found an easy way to obtain the testing on his own. Within a couple of weeks, he returned to his online community and shared all his information. Within moments, he was provided useful discussion to help him understand the values, all leading to changes in nutrition, nutritional supplement choices, how and where to get the simple tools necessary, such as iodine and vitamin D supplements. He even entered his data, choosing which values he was willing to share with others, which remained private, allowing him to compare his own follow-up values several months later. Engaged in this process, self-directed but collaborative, he witnessed marked transformations in his health. Not only did he never again—over several years—ever re-develop heart symptoms nor require any more trips back to the cath lab, he lost weight, reversed a pre-diabetic sugar profile, improved his cholesterol values without drugs, got rid of the acid reflux symptoms he endured for many years, dropped his blood pressure to normal, enjoyed better mood, energy, and sleep. Slender, healthier, all accomplished without his doctor. 

Harold returned to his doctor for a routine follow-up. Slender, energetic, without complaints, on no drugs except the aspirin for his stent, the basic laboratory assessment his doctor ordered in front of him, his doctor admitted,” Well, I don’t know how you’re doing it, but these values look like a 20-year old substituted his blood for yours. They’re unbelievable. What drugs are you taking to do this?” “No drugs,” Harold replied, “I’m following a program to reverse heart disease, but it means doing some things that are different from conventional solutions.” His doctor closed their meeting with the signature response of doctors nationwide: “Well, I don’t understand what you are doing, but just keep doing it.”

Yes, Harold knew more about how to control heart disease than his doctor, more than his cardiologist. The cardiologist knew how to insert a stent or defibrillator. But deliver information that empowered Harold in all aspects of health from head to toe, while also dramatically reducing, perhaps eliminating, his coronary disease risk? As you now know, that is not what conventional healthcare does, nor is it interested in doing so, as it would relinquish control and threaten to cut off this hugely profitable revenue stream that drives “healthcare.”

Having managed to inadvertently create a self-directed coronary risk management program with such spectacular results and in probably one of the most difficult areas of all—heart disease—it became clear that a similar approach could be even more easily applied to many other areas of health, such as weight loss, bone health, cholesterol and blood pressure issues, diabetes and pre-diabetes, hormonal health, autoimmune conditions, and others. You can do it when empowered by safe, effective information, and supported by a community of sharing and collaboration. We don’t fire our doctors; they are there when we need them when, for instance, we get injured or catch pneumonia, or as an occasional resource. But doctors should no longer be able to get away with neglect, misinformation, or blindly directing you to the next revenue-generating procedure because you are empowered by the information and support you receive in Cureality.

As we get more effective in delivering this information and new tools to you, just imagine what we can accomplish in this new age of information and self-empowerment. The future for us is bright with ambitions for better interactive tools with Cureality expert staff, better ways to crowd source health answers, provide more engaging community conversation, all while the health insights that help accomplish our self-directed health goals get better and better. Each person that joins Cureality helps make this service more effective because your wisdom, insights, and experience are added to the collective knowledge. We are more powerful together than we are as individuals.

If you are already a Cureality Member, please add your comments and questions to the growing conversation. If you are not a Member, consider joining our discussions, as each new voice gets us closer and closer to better answers to take back control over health.
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Third heart scan a charm

Third heart scan a charm

It struck me recently that, for many people, it's not the second but the third heart scan that more commonly shows a reduction in score.

I think this is because many people's reaction to their first heart scan is "This can't be. There's no way my arteries have that much plaque." They then follow a half-hearted program to correct their patterns.

When the second heart scan shows a significantly higher score, that really catches their attention. This is when they finally buckle down and give it their all.

Only the occasional person will, after the first heart scan, seize full control and take their program very seriously. These tend to be highly motivated people.

Don't feel too bad if your second heart scan score shows an increase. Look at it for what it represents: feedback on the adequacy of your program.
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Man walks after removing wheat

Man walks after removing wheat

No, this isn't some National Enquirer headline like "Woman delivers alien baby."

Tom is a 26-year old man with a complex medical condition, a malformation he was born with and has had reconstructed. Aside from this, he leads a normal life: works, is married, and is, in fact, quite intelligent.

He came to me for an opinion regarding his overall health. Tom was worried that his congenital condition would impair his long-term health and longevity prospects, so he wanted to optimize all other aspects of his health.

But, when I examined Tom, he could barely get himself up on the exam table without wincing in pain. When I asked him to walk, he hobbled a few steps, again clearly in pain. When I asked him what hurt, he said "everything." He said that all his joints hurt just to move.

He told me that his several doctors over the years didn't know why he was in such pain: It wasn't rheumatoid arthritis, gout, pseudogout, or any of the other inflammatory joint diseases that might account for virtually incapacitating this 26-year old man. Even the rheumatologists were stumped. It was also unrelated to his repaired congenital condition. So Tom went on with his life, barely able to even go for a walk with his wife without pain, slowing him down to the pace of an 80-year old.

So I suggested that he eliminate all wheat products. "I don't know for a fact whether it will work, Tom. But the only way to find out is to give it a try. Why not try a 4-week period of meticulously avoiding wheat? Nothing bad will come of it."

He and his wife look perplexed, but were so desperate for a solution that they agreed to give it a try.

Tom returned 6 weeks later. He walked into the room briskly, then bounded up on the exam table. He told me that, within days, all his joint pains had completely disappeared. He could walk, stretch, do all the normal physical things with none of the pain he had suffered previously.

Tom told me, "I didn't think it could be true. I thought it was just a coincidence. So I had a sandwich about 2 weeks into it. In about 5 minutes, I got about half my pains back."

Tom now remains wheat-free and pain-free, thankfully with no discernible joint impairment.

So, yes, Tom walked freely and without pain simply by eliminating wheat from his life.

Is it an immune phenomenon? Does wheat gluten trigger some inflammatory reaction in some people? There is surely something like this underlying experiences like Tom.

Wheat contains far more than gluten. Modern wheat is a collection of hundreds of different proteins, though gluten is the most plentiful, the one that confers the "viscoelasticity" of dough. But there's plenty more to wheat than gluten or celiac disease.

Comments (27) -

  • loco

    5/9/2010 2:04:43 PM |

    Maybe Monsato knows what causes it.

  • Nancy

    5/9/2010 2:04:43 PM |

    This is similar to what happened to me, although it took a lot longer.  I was diagnosed with Ankylosing Spondylitis and had pain in almost every joint.  Removing gluten from my diet and in about a year my AS went into remission and I am feeling so much better.

  • loco

    5/9/2010 2:06:50 PM |

    Scratch that.  Amazingly wheat is one of the few product "monsanto" doesn't touch.

  • Lori Miller

    5/9/2010 2:40:44 PM |

    After cutting way, way back on the carbs (and eliminating wheat), my little aches and pains, sinus headaches and fatigue disappeared. My skin is better, too. Oh, and I'm back to what I weighed in high school. I'm so happy with my new diet that it's hard not to proselytize.

  • Darrin

    5/9/2010 4:43:35 PM |

    It's interesting how little attention is paid to gluten intolerance, and more generally grain intolerances, in humans.

    In contrast, it is quite easy to find statistics on the amount of the world's population that is lactose intolerant and which populations are most susceptible.

    Quite the eye-opening post.

  • Mike Turco

    5/9/2010 8:27:19 PM |

    I have a story that is somewhat similar. I've had chronic neck and back pain for years. Nothing debilitating but it was "there" every day, sometimes for many hours. I was taking way too much ibuprofen to manage the discomfort.

    Anyways, I read an article in the news somewhere about how "we" all sit in chairs too much, that the human body wasn't meant to do that kind of thing, and that doing so could lead to chronic neck and back pain! The suggestion was to use a standing desk.

    Being a bit of a cheapskate, I setup a shelving unit about two weeks ago, put my computer and so forth up on the shelf, and gave it a shot.

    Literally, the next day my back and neck pain was gone. Just gone. Hasn't come back. In addition, my weight loss efforts seem to be doing a little better. Hey, its not much exercise, but its certainly a better "workout" than sitting on my duff all day.

    Granted, I've only been at this for two weeks and its too early to tell whether any of the affects are real or just coincidental. Still, though, I'd recommend to just about anybody that they give a shot at standing up throughout their workday instead of sitting down. It can't hurt anything, I think, and its worth a try.

    Mike

  • Anonymous

    5/10/2010 11:57:24 AM |

    Apparently, nobody cares about wheat. It's been this way for 15 years. It's like trying to convince people that earth is round rather than flat. We have a long way to go. Frustrating when we have Federal Government promoting low fat, high carbs diet.

  • scall0way

    5/10/2010 1:56:05 PM |

    I believe it. Most of my aches and pains went away when I eliminated wheat also. I used to almost have to crawl out of bed in the morning, which I attributed to "getting old". Yet not one single doctor ever once suggested my diet could have anything to do with the problem.

  • Fred Hahn

    5/11/2010 12:05:31 AM |

    Bill -

    You should send this story to Oprah!

  • WheatFreeNow

    5/11/2010 5:28:19 AM |

    Not surprising at all! :0  It's going to become more and more common to see results like this - and yes - I agree with your point about the problem being SO MUCH more to do with the gluten issue - it's more about the over commercialized, genetically modified wheat that has entered our diet which is probably causing the problem.

  • Dr. William Davis

    5/11/2010 11:45:28 AM |

    Hi, Fred!

    I was so impressed when I heard you talk that you mentioned the grain-rheumatoid arthritis connection. That's a pretty obscure relationship, but one I, too, am convinced is real.

  • Ned Kock

    5/11/2010 2:47:31 PM |

    This type of case must be very rewarding for a doctor.

    Not only did you save this person's life with your advice, his quality of life improved dramatically.

  • monte

    5/11/2010 5:13:34 PM |

    I also was diagnosed with Ankylosing Spondylitis when I was 20 years old. I'm now 42 and have had both of my hips replaced. I read another article about the dangers of gluten:
    http://www.huffingtonpost.com/dr-mark-hyman/gluten-what-you-dont-know_b_379089.html

    I've been off wheat now for about 4 months and the inflammation is almost completely gone. When I started I could only walk about 3 blocks but I'm up to a mile now and without the extreme pain in my joints. I still have a lot of therapy to do but I'm actually hopeful about my health for the first time in years.

    Thanks for getting this info out to people!

  • Anne

    5/11/2010 7:12:09 PM |

    My knee pain was the first thing that disappeared when I stopped eating gluten. That was 7 yrs ago and still doing well. I wake up in the morning with no joint pain. Not bad for 67 yrs.

  • Anonymous

    5/11/2010 8:06:08 PM |

    Yup, my mother-in-law was diagnosed with rheumatoid arthritis back in the '70s.  I convinced her to give up wheat a year ago and all her pains went away.  

    I'm convinced many "diseases" are actually symptoms of various food intolerances, with wheat being the most likely suspect.

  • Professor Tom

    5/12/2010 2:14:50 PM |

    Are you claiming that everyone should eliminate wheat from their diet?

    What about the recent attacks on sodium from the UN in the form of Codex Alimentarius? Personally, I think it's more about control as I documented here

  • DrStrange

    5/12/2010 2:56:39 PM |

    "I'm convinced many "diseases" are actually symptoms of various food intolerances, with wheat being the most likely suspect."

    More specifically gluten, so we need to include rye, barley, tritcale, spelt, kamut, in that.  Also dairy #2.  If it does not bother your individual body, it does not.  But for so many one or both of there are disasters.

    The hardest part, second after the addiction/cultural promotion of them as good, healthy foods, is that it can take many days of zero intake before improvement is really noticeable.  People are so emotionally attached to what they eat they fight tooth and nail against giving something up for that long "just to see." That is of course, unless/until they are truly desperate!

  • TedHutchinson

    5/13/2010 10:44:10 AM |

    Dr Dr Davis
    I think I may have mistakenly posted a link to an review on Resolution of Adipose Tissue Inflammation that I intended as a reply to a different blog.
    Although it's an interesting paper confirming the importance of the role of omega 3, it is off topic for this particular thread. I'd be pleased if you could delete it.Many thanks Ted

  • Anonymous

    5/13/2010 5:05:29 PM |

    I used to have severe menstrual cramps from the time I hit menarche. And miraculously they went away last year after I gave up wheat.

    MB

  • Neonomide

    5/15/2010 12:55:01 AM |

    Loren Cordain has written a paper on the role of dietary lectins in rheumatoid arthritis:

    http://www.thepaleodiet.com/articles/Arthritis%20PDF.pdf

  • Neonomide

    5/15/2010 2:23:45 AM |

    How convenient - this brand new Cordain's Paleo newsletter has some information on the subject as well:



    Q: Could you suggest recent scientific articles on the topic of dietary lectins and rheumatoid arthritis?

    Many thanks,
    Allena

    A: Dear Allena,

    To my knowledge, there are no recent studies addressing the role of a paleolithic diet and its implications in rheumatoid arthritis, except from that of Dr. Cordain. On his DVD How to Treat Multiple Sclerosis with Diet, Dr. Cordain thoroughly explains the dietary mechanisms of autoimmunity in MS which are almost the same for all autoimmune diseases, including RA. These include: increased intestinal permeability, increased passage of luminal antigens into peripheral circulation, molecular mimicry and genetic susceptibility (genes encoding for the HLA system), among other factors.

    In recent years, new substances have been discovered which might be responsible for increased intestinal permeability - namely saponins - found in legumes, potatoes, soya, quinoa, amaranth, alfalfa sprouts or tomatoes. If you've seen Dr. Cordain's scientific paper entitled "Modulation of immune function by dietary lectins in rheumatoid arthritis", I am sure you are aware of the role lectins play in autoimmunity.

    Adjuvants are used by immunologists in order to boost the immune system and induce immune response. It turns out that certain foods possess bioactive compounds that have adjuvant-like activity. This is the case for tomatoes or quillaja (a foaming agent used in beers and soft drinks).

    Gliadin is a prolamine found in wheat which has been shown to increase intestinal permeability, and hence the risk of suffering from an autoimmune disease. While several clinical trials conducted have shown promising results, unfortunately they have used a gluten-free diet or vegan diet instead of a whole paleolithic diet, which we think is superior.

    In the vegan diets, authors often claim that the benefits cited might be due to the lack of meat, but we think the positive effect relies on the lack of diary proteins and gluten. Meat has historically been seen as the "bad guy" of inflammation, but the data to support that notion is not sufficiently compelling.

    Listed below are some references that may be helpful.

    Cordially,
    Maelán Fontes

    References:

    1: Modulation of immune function by dietary lectins in rheumatoid arthritis. Cordain L, Toohey L, Smith MJ, Hickey MS. Brit J Nutr 2000, 83:207-217.

    2: Gluten-free vegan diet induces decreased LDL and oxidized LDL levels and raised atheroprotective natural antibodies against phosphorylcholine in patients with rheumatoid arthritis: a randomized study. Elkan AC, Sjöberg B, Kolsrud B, Ringertz B, Hafström I, Frostegård J. Arthritis Res Ther. 2008;10(2):R34. Epub 2008 Mar 18.

    3:A vegan diet free of gluten improves the signs and symptoms of rheumatoid arthritis: the effects on arthritis correlate with a reduction in antibodies to food antigens. Hafström I, Ringertz B, Spångberg A, von Zweigbergk L, Brannemark S, Nylander I, Rönnelid J, Laasonen L, Klareskog L. Rheumatology (Oxford). 2001 Oct;40(10):1175-9.


    So gliadin in wheat seems to be an important bad guy, eh ?


    PS: Thank you so much Dr Davis for bringing information on wheat havoc  to the masses. It's very much appreciated!

  • Felix Olschewski

    5/21/2010 7:13:12 AM |

    Dr. Davis,
    I hope you don't mind that I have (kind of) translated this post into German and published it on my Blog. You can find it on http://www.urgeschmack.de/schmerzfrei-getreideverzicht/

  • Carrie

    6/23/2010 12:03:56 PM |

    With a few exceptions, I have found those who comment on this blog to be very well informed, adding wonderful references, insights and experiences to the conversation.

    @Professor Tom; even a rudimentary glance of Dr. Davis' blog would reveal that he does not think EVERYONE should stop eating wheat, but for his heart patients, patients with pain and inflammation, patients with neurological disorders, and patients with weight, blood sugar and hormonal imbalances, or other serious and chronic health conditions he advises them to TRY 4 weeks of completely avoiding all wheat/gluten and see if it makes a difference, and in 70% of people it does.  

    It is not some kind of mind control conspiracy theory to make us into docile sheep.  It is the opposite in fact.  He is helping people regain their health by bucking convention; opting out of the wheat based culture and freeing ourselves from dependence on pharmaceuticals.  

    I have seen miraculous health results of going totally grain free for 3 members of my family.  Personally, I only experienced weight loss and increased immunity but that is still worth it.

  • Neonomide

    6/23/2010 1:57:19 PM |

    Carrie,

    I've had a different impression. I understand that Dr Davis does not consider wheat to be human food at all and as a paleo scholar, I completely agree.

    I also acknowledge that all wheat is not equal - here in Finland I think wheat elimination alone will not show as dramatic effects as in US. Different genome, in both humans and wheat itself.

    In energy versus nutrient equations wheat loses anyway and added salt further unbalances the essential sodium/potassium ratio that is very important in BP control and kidney health. Antinutrient in wheat are a great way to weaken your micronutrient status. The greens and berries own wheat every time.

    IMHO, playing risk game with not-yet-sick people with catastrophe food like wheat is simply stupid. When wheat derived autoimmune disease starts to take it's toll, it may not be reversed anymore. As for sdLDL, it may not cause symptoms at all before the first MI. Then you're dead or in the risk risk of sudden death for the rest of your life. Not fun.

  • hernia surgery Los Angeles

    12/22/2010 10:27:24 AM |

    That is amazing if you could detect something so smoothly and it worked...it's like a miracle or a magic.Why is gluten bad and for all joint pains?

  • Geoffrey Levens

    12/22/2010 3:52:33 PM |

    I would not say that gluten is bad!  What is bad or damaging is many individuals (NOT all) physiological reaction to it.  If you are reactive to gluten, then it is systemically inflammatory.  If you have poor blood sugar regulation, then wheat (maybe its the gluten?) can dramatically raise blood sugar and elevated blood sugar is also inflammatory.

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Small LDL: Perfect index of carbohydrate intake

Small LDL: Perfect index of carbohydrate intake

Measuring the number of small LDL particles is the best index of carbohydrate intake I know of, better than even blood sugar and triglycerides.

In other words, increase carbohydrate intake and small LDL particles increase. Decrease carbohydrates and small LDL particles decrease.

Why?

Carbohydrates increase small LDL via a multistep process:

First step: Increased fatty acid and apoprotein B production in the liver, which leads to increased VLDL production. (Apoprotein B is the principal protein of VLDL and LDL)

Second step: Greater VLDL availability causes triglyceride-rich VLDL to interact with other particles, namely LDL and HDL, enriching them in triglycerides (via the action of cholesteryl-ester transfer protein, or CETP). Much VLDL is converted to LDL.

Third step: Triglyceride-rich LDL is "remodeled" by enzymes like hepatic lipase, which create small LDL.


Carbohydrates, especially if they contain fructose, also prolong the period of time that triglyceride-rich VLDL particles persist in the blood, allowing more time for VLDL to interact with LDL.

Many people are confused by this. "You mean to tell me that reducing carbohydrates reduces LDL cholesterol?" Yes, absolutely. While the world talks about cutting saturated fats and taking statin drugs, cutting carbohydrates, especially wheat (the most offensive of all), cornstarch, and sugars, is the real key to dropping LDL.

However, the effect will not be fully evident if you just look at the crude conventional calculated (Friedewald) LDL cholesterol. This is because restricting carbohydrates not only reduces small LDL, it also increases LDL particle size. This make the calculated Friedewald go up, or it blunts its decrease. Conventional calculated LDL will therefore either underestimate or even conceal the real LDL-reducing effect.

The reduction in LDL is readily apparent if you look at the superior measures, LDL particle number (by NMR) or apoprotein B. Dramatic reductions will be apparent with a reduction in carbohydrates.

Small LDL therefore serves as a sensitive index of carbohydrate intake, one that responds literally within hours of a change in food choices. Anyone following the crude Friedewald calculated LDL will likely not see this. This includes the thousands of clinical studies that rely on this unreliable measure and come to the conclusion that a low-fat diet reduces LDL cholesterol.

Comments (15) -

  • nitrile exam gloves

    12/8/2009 3:58:05 AM |

    Thanks for the knowledge sharing...it helps to be healthy.

  • x.ds

    12/8/2009 12:02:31 PM |

    Here is a link showing the atherogenicity in mice of different saturated fats in diets with 1% cholesterol. Look at page 1416 of the free full report that can be downloaded here:

    http://www.ncbi.nlm.nih.gov/pubmed/8409772

    On the opposite you can see bread not being atherogenic in baboons here:

    http://www.ajcn.org/cgi/content/abstract/33/8/1869

    By the way you can notice the effect of 0.1% cholesterol at the end of the article = 1 gm cholesterol per kg of food = 5 egg yolks.

    Does it look a lot ? "There is evidence from animal experiments showing that if atherogenic dietary factors are reduced to levels comparable to man's intake, the same vessel changes occur as with higher levels, but more slowly."

    Download the free full report here:

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1938976/

    In this report you can also see butter to be highly atherogenic to swine without additional cholesterol to their diet.

  • Bobber

    12/8/2009 5:06:03 PM |

    What about rice?  Does it also increase small LDL particles?

  • Nigel Kinbrum BSc(Hons)Eng

    12/8/2009 6:54:52 PM |

    @x.ds: Humans aren't C57BL/6J mice (susceptible to diet-induced fatty streak lesions), baboons or pigs.

  • Future Primitive

    12/8/2009 7:34:20 PM |

    @x.ds

    The strain of mice in the first study are predisposed to diet-induced obesity, type 2 diabetes, and atherosclerosis.

    Likewise, here's an interesting quote from the last paper based on a porcine model: "Whenever there are three
    animals from the same litter, they are divided equally among the three groups (ie, "control", "butter", & "egg yolk" groups)  In the present experiment, this occurred once. These three pigs had the most aortic atherosclerosis in their respective groups. The control pig with the most atherosclerosis was the brother of the pigs with the most disease fed egg and butter."  

    The group of pigs with the highest rate of atherosclerosis was the egg yolk group - yet at most we see a vanishingly positive relationship, if any, in a large number of human epidemiological studies of moderate egg consumption and heart disease (too many to list here - many are recent and easy to locate, though).  Do we even have grounds to formulate a hypothesis of egg induced atherogenesis based on human observational studies? I don't know, really - though a casual glance suggests, "no".

    Looking forward to reading the other study you pointed us to when I get the time.

  • Anonymous

    12/8/2009 7:42:17 PM |

    x.ds:

    Often times these animal studies don't translate well when applied to humans.

    Also, like Dr. Davis pointed out in his blog, most (LDL) cholesterol lowering research doesn't use advanced lipoprotein testing like NMR so the data is misleading to say the least.

  • Anonymous

    12/8/2009 9:16:54 PM |

    x.ds:

    It would be nice for a change to see experiments on other than herbivorous (mice) or mostly vegetarian animals (both pigs and baboons on the wild).

  • Dr. William Davis

    12/8/2009 11:48:34 PM |

    Bobber--

    While all carbohydrates increase small LDL, the effect of wheat is the most extravagant.

  • Anon X

    12/9/2009 3:18:19 AM |

    I generally agree with those who deny the universal applicability of experimental results in mice and rats to men. However, I do so with this one caveat; there is one fact I cannot deny: Many women are convinced that most men are rats.

  • LynP

    12/9/2009 4:42:51 AM |

    Doc, does this mean that I ca sorta log my particle size by getting my apoB checked in quarterly labs? I'll never be able to convince primary to do the outright particle size test...yet (working on that). Thnx.

  • Anonymous

    12/9/2009 3:08:55 PM |

    I admit I do not understand VLDL-C. What I would really like to find is a simple range scale. Mine shows up VLDL-C..7  Non HDL ..70
    I do not know if that is good or bad. Is there such a chart showing like,  1 good ... 100 bad ??
    LP(a) shows up by itself and I understand that because there is a range showing bad ..over 30.
    Any help understanding appreciated

  • David

    12/10/2009 2:39:45 AM |

    Dr. Davis,

    I honestly think you are doing God's work and have learned to appreciate the value of heart scans through your site.  However, it still bugs me that so many people in Asia can live off of large quantities of white rice with minimal atherosclerosis.  For instance, this study shows that American Whites have much higher atherosclerosis than Japanese despite the Japanese having much higher LDL-cholesterol, blood pressure, fasting glucose, and smoking rates:

    http://ije.oxfordjournals.org/cgi/content/full/34/1/173


    This other study (below) tries to explain this difference based on the Japanese consumption of fish. However, if you look at the data, those Americans who consume the most fish oil consume about as much fish oil as those Japanese that consume the least fish oil, and yet between these comparable groups in terms of fish consumption, the Japanese still have vastly lower atherosclerosis on heart scans.  And the Japanese American group consumes more fish than the White American group and has more coronary calcium.

    http://content.onlinejacc.org/cgi/content/full/52/6/417


    And here is another study showing much lower CAC in Japanese than in Japanese-Hawaiians even after controlling for a bunch of risk factors including fish intake:

    http://aje.oxfordjournals.org/cgi/content/full/166/11/1280


    Although in this other study looking at only at Americans, the incidence of CAC appears to be similar to that in Japanese - so maybe there was something unusual about the US samples in the other studies?

    http://content.onlinejacc.org/cgi/content/full/49/20/2013

  • Anonymous

    12/10/2009 8:23:46 PM |

    Dr. Davis,
    What is your opinion of the LP-Pla2 test for arterial plaque?  If you've used the test, do any elements of your program reduce levels of this enzyme?

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    11/3/2010 9:44:57 PM |

    However, the effect will not be fully evident if you just look at the crude conventional calculated (Friedewald) LDL cholesterol. This is because restricting carbohydrates not only reduces small LDL, it also increases LDL particle size. This make the calculated Friedewald go up, or it blunts its decrease. Conventional calculated LDL will therefore either underestimate or even conceal the real LDL-reducing effect.

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To learn how to eat . . . try fasting

To learn how to eat . . . try fasting

Curious thing about fasting: It teaches you how to eat.

In previous posts, I've discussed the potential benefits of fasting: reduction of blood pressure, reduction of inflammatory responses, drop in blood sugar, weight loss, and reduced heart attack risk. In my recent Heart Scan Blog post, Fasting and Heart Disease, I discussed the just-released results of a study in people who fast for religious reasons and experience less heart disease.

Fasting can mean going entirely without food and just making do with (plenty of) water, or it can mean variations on "fasting" such as vegetable juice fasts, soy milk fasts, etc.

How can fasting teach you any lessons about food and eating?

People who fast will tell you that the experience:

--Helps you appreciate food tastes when you resume eating. After a fast, flavors are stronger; sensations like sweet, sweet, or salty are sharper; you become reacquainted with the variety of wonderful food textures.

--Makes you realize how you ate too much before your fast. After a fast, you are satisfied with less. You will eat more for taste and enjoyment, less for satiety and mindless indulgence.

--Makes you more mindful of the act of eating. For many of us, eating is an automatic activity that provides fleeting satisfaction. After a fast, each bite of food brings its own special enjoyment.

--Reveals to you how awful you felt when many foods were eaten. For example, many people are physically slightly ill after eating pancakes, pizza, or other highly processed foods but cease to recognize it. Remove the offensive foods entirely and you might realize just how bad you felt.

--Takes away fear of hunger. Many people have a gut-wrenching fear of hunger. It's probably partly instinctive, that animal-like fear of not knowing when your next meal is coming, partly the abnormal, artificial drive to eat ignited by processed foods like wheat and corn syrup.

--Makes you realize just how much of your day is spent in some activity associated with food. Shopping, eating, cleaning up afterwards, thinking and talking about food all occupy an extraordinary portion of everyone's life. A fast can open your eyes to just how much time is spent in these pursuits. Sometimes, gaining an awareness of a mindless, repetitive behavior can provide the first step towards changing direction.


Most people consider a fast for rapid weight loss. But fasting is far more than that. Perhaps fasting has become an integral part of many religious practices because of its capacity for enlightenment, reawakening, revelation, but not of only the spiritual, but also of how far many of us have strayed in diet.

Fasting is what Omnivore's Dilemma author Michael Pollen might describe as looking the pig you're about to eat in the eye, an opportunity to open your eyes to what it is you 've been doing all these years.

Comments (13) -

  • Anonymous

    11/18/2007 6:40:00 AM |

    Thought provoking article. I have never fasted before, and would like to try it out.

    Can you suggest any resources online that describes about how one can fast the right way - the pre-fast preparation, fasting period and post fast recovery? You did touch on these briefly in your previous articles; I was curious if there were any resources out there that you would recommend.

  • Dr. Davis

    11/18/2007 1:47:00 PM |

    Two sources of information on fasting: The Track Your Plaque Special Report, Fasting: Fast Track to Plaque Control, a report on fasting to gain control over coronary risk.

    Also, Dr. Joel Fuhrman's book, Fasting and Eating for Health, is an excellent resource. (But I tell my patients to ignore much of the "low-fat" commentary, which is outdated.)

  • Nancy M.

    11/18/2007 3:22:00 PM |

    I've been doing something called "Intermittent Fasting" where you extend your overnight fast either by skipping or delaying one or two meals the next day.  There's been some study of it by the folks who study calorie restriction.  It isn't calorie restriction but seems to offer the same sort of changes that CR does.  

    Dr. Eades had an interesting blog post about it here: http://www.proteinpower.com/drmike/2006/09/13/fast-way-to-better-health/

    That got many of us "low-carbers" interested, some of which were pre-diabetic or T2 diabetic.  Many of those people with glucose control issues have seen their fasting glucose levels plummet by incorporating IF into their low carb routine.

    If heart disease is driven by excess blood glucose and insulin, then anything that gives your body a little rest is probably a good thing.

    Oh, I can vouch for the fact that food tastes EXTREMELY good when you're fasting most of the day. Smile
    Nancy

  • Dr. Davis

    11/18/2007 4:07:00 PM |

    Hi, Nancy--

    Interesting perspective!

    I wonder if the intermittent fasting approach of skipping breakfast and lunch has an effect on metabolic rate. I suppose you can't argue with success!

    Also, thanks for bringing Dr. Eades blog to my attention. He's got a lot of interesting ideas.

  • JoeEO

    11/18/2007 9:50:00 PM |

    I think that having an interview with Dr Eades (both) would be a great addition to this blog (or the typ site). I think that he is one of the best bloggers on the whole internet.

    I recall, in one particular post that might be interesting to TYPers, Dr Mike Eades mentioned that he stopped prescribing niacin for his patients as he found that a low carb diet had most of benefits of niacin - he was speaking of LDL  particle numbers and size and HDL.


    Peace,

    Joe E O

  • Dr. Davis

    11/18/2007 11:38:00 PM |

    Hi, Joe--

    Wonderful idea!

    I also agree with the idea that niacin and weight loss/carbohydrate restriction achieve similar effects. However, there are indeed people with such severe disorders to start with (e.g., HDL 25 mg/dl, called hypoalphalipoproteinemia, or triglycerides of 500 mg/dl, called familial hypertriglyceridemia, or genetic defects in some other pathways that are not uncommon) that do indeed necessitate niacin.

    Also, when your goal is not just correction of cholesterol or lipoproteins, but REVERSAL of heart disease, we push our patients harder.

  • Anonymous

    11/19/2007 6:14:00 PM |

    Talking about how fasting can help with heart disease, and presumably with helping to control glucose and lipids levels, have you heard if donating blood will help in correcting lipid #s?

  • Dr. Davis

    11/19/2007 11:54:00 PM |

    No, sorry, never heard of that. Blood donations reduce iron, but I've never heard of any effect on lipids or lipoprotein patterns.

  • Vesna Vuynovich Kovach

    11/20/2007 1:05:00 AM |

    A word od caution. For some people, fasting can have just the opposite effect. It can derail one's sense of appetite and proper eating practice. I've been there.

  • Anonymous

    11/27/2007 3:25:00 AM |

    I understand that complete fasting can cause muscle wasting.  Conversely (and surprisingly) intermittent fasting has anabolic effects.  (In other words, the bodybuilder's dogma that you need a constant flow of protein to build muscle isn't true.  What's effective is a large portion of protein in a single meal a day, and then nothing the rest of the day.)

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