Cholesterol follies

Rudy is a 59-year old man. He's had three heart catheterizations, two of which resulted in stent implantations. Obviously, Rudy should be the beneciary of a prevention program.

His basic cholesterol values:

Total cholesterol 164 mg/dl--pretty good, it seems.

LDL cholesterol 111 mg/dl--Wow! Not too bad.

HDL cholesterol 23 mg/dl--Uh oh, that's not too good.

Triglycerides 148 mg/dl--By national (NCEP ATP-III) guidelines, triglycerides of 150 mg/dl and below fall within the desirable range.


So we're left with an apparently isolated low HDL cholesterol, nothing more. On the surface, it doesn't seem all that bad.

Of course, we need to keep in mind that this pattern landed Rudy in the hospital on several occasions and prompted several procedures.

Should we rely on these results? How about Rudy's lipoproteins?

Here they are (NMR; Liposcience):

LDL particle number 2139 nmol/l--Representing an effective LDL of 213--over 100 mg higher than the standard value (above) suggests.

Small LDL particles 2139 nmol/l--In other words, 100% of all Rudy's LDL particles are small. (Thus, weight-based measures of LDL cholesterol fail to tell us that he has too many small particles.)

Large HDL 0 (zero) mg/dl--Rudy has virtually no functional HDL particles.


If we had relied only on Rudy's standard cholesterol values, we would have focused on raising HDL. However, lipoprotein analysis uncovered a smorgasbord of additional severe patterns. The high LDL particle number comprised 100% of small particles is especially concerning.

Truly, conventional cholesterol testing is a fool's game, one that time and again fails to fully uncover or predict risk for heart disease. One look at Rudy's lipoproteins and it becomes immediately obvious: This man is at high risk for heart disease and the causes are clear.

Of course, many physicians and insurance companies argue that the added information provided by this portion of the lipoprotein test added around $70 more to the expense.

When you see results like this, is there even a choice?

Comments (5) -

  • Thomas

    1/11/2008 4:02:00 AM |

    It's this type of analysis that's most instructive and most interesting. If I were 20 years younger reading this post, I'm confident I'd have avoided open    heart surgery I went through this past April.

  • Andy

    1/11/2008 1:04:00 PM |

    I couldn't find another place to give you general feedback, so it goes here:  thanks for what you do.  

    I've been an insulin dependent diabetic for 6 years now with a family history of CAD.  While I have moderately good scores (59 for HDL, triglycerides below 60), I've been concerned about getting a better picture.

    I had a CT Heart Scan Wednesday, which resulted in a wonderful 0 reading.  While I plan to push my family practitioner for NMR tests in the future, it's nice to get some validation now.  At $125, the price was a major bargain, as well.

    Again, thanks for sharing what you know.

  • Dr. Davis

    1/11/2008 1:19:00 PM |

    Well, then, more to come!

  • keith

    1/11/2008 1:40:00 PM |

    Interestingly, given a LDL particle count of 2139, Rudy would have been better off with a LARGER standard LDL cholesterol value, as this would imply his particles were larger and hence less atherogenic.

  • Dr. Davis

    1/11/2008 5:07:00 PM |

    Yes, ironically.

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A tan does not equal vitamin D

A tan does not equal vitamin D

The sun is getting stronger and the days are getting longer, even here in Wisconsin.

Some people are coming to the office with nice tans obtained by sunning themselves for several hours. Others have come back from winter getaways to Florida, Arizona, or the tropics, also sporting nice, dark tans.

Several people, in fact, were so confident that sunning themselves provided sufficient vitamin D that they reduced their usual dose. Some even stopped their vitamin D altogether.

But, when blood levels of 25(OH) vitamin D were checked, they were virtually all low, sometimes as low as <20 ng/ml. Yet all had nice tans.

Why does this happen? Why would people with dark tans remain deficient in vitamin D?

One big factor is age: Anyone over 40 years old is fooling themselves if they think that a tan ensures raising vitamin D levels to a desirable range. Also, the more you tan, the more melanin skin pigment accumulates, and the more vitamin D activation in the skin is blocked.

Weight is another factor: Heavier people need more vitamin D, sometimes three- or four-fold more than slender people.

Why does aging result in inefficient skin activation of vitamin D? It seems that, once we are beyond our reproductively useful years, this ticking clock of aging gets triggered. The older we get, the less activation of vitamin D occurs in our skin, the less of the youth-maintaining, disease-preventing benefits of vitamin D we obtain with sun exposure.

The message: Don't rely on a tan to gauge the adequacy of vitamin D. Maybe that works when you're 16 years old, but not at age 50 or 60. There's only one way to know your vitamin D status: a blood level of 25(OH) vitamin D.


Copyright 2008 William Davis, MD

Comments (8) -

  • Anonymous

    5/14/2008 10:03:00 AM |

    It's all about UVB exposure and amount of pigment and cholesterol in the skin.

  • ethyl d

    5/14/2008 4:36:00 PM |

    Just to clarify, I assume therefore, that, even if sunshine exposure does not guarantee adequate vitamin D levels as one ages, dietary vitamin D through D-rich foods or gel capsules do?

  • Ross

    5/14/2008 5:23:00 PM |

    Still another factor is that tanning lotions and sunscreens selectively block UVB rays, which are the higher-energy rays our bodies need to synthesize Vitamin D.  The lower-energy UVA rays that cause tanning but don't help with Vitamin D are permitted through in much higher quantities by all sunscreen chemistries.

    Like many things in this world, when we humans interfere with the natural, we tend to screw it up.  Just like we're better off with whole milk, whole eggs, whole meats (leave the skin on the chicken, it's the best part!), etc.  We also benefit most from the whole spectrum of sunlight.  Not so much that we burn, but definitely not filtered of the best and most useful components.

    If you want a tan to count towards your Vitamin D, repeatedly get outside for short periods of time without sunscreen.  I'd still recommend a supplement, since your body has all sorts of ways to manage too much, and very few ways to manage not enough.

  • Anonymous

    5/14/2008 11:32:00 PM |

    Dr. Davis, thank you for reminding us of the importance of vitamin D supplementation.   When addressing vit. D supplementation, please, we need to keep on stressing that it needs to be D3 in GEL CAPS.   There are lots of people who are hearing the vit D supplementation message, run to the drugstore and buy D tablets (often 1000 IU D2).  Their doctors and pharmacists are saying they are doing the right thing.  But from what I understand it is rather useless.  Oil based D3 in the right, larger, quantity, is what matters, because that is what the digestive system can absorb.

    Could you provide a medical research reference that clearly shows why D3 in gel caps is the only way to go?  I would like to print lots of copies to give to my friends, parents, etc....

  • Anonymous

    5/16/2008 1:11:00 PM |

    A test comparing D2 to D3:

    http://www.nutraingredients.com/news/ng.asp?id=82331

  • Anna

    5/16/2008 6:50:00 PM |

    Check out the Vitamin D Council for a wealth of research on Vit D supplementation:  http://www.vitamindcouncil.org/

    I was so impressed with this non-profit's work that I added them to my list of charitable causes.

  • Anne

    6/9/2008 7:56:00 PM |

    Dear Dr Davis,

    I just got back from my holidays in France and am catching up with your blogs. This one interested me. I just received the results of my vitamin D test taken before I went away, the 25(OH)vitamin D3 test, and my levels are 384 nmol/L (153 ng/ml) which I understand is much, much too high.

    I am mystified at this result as I live in the UK where there isn't usually much sun and I don't sunbathe anyway and I've been taking 4,000iu D3 only since January. Obviously I am stopping the supplements right away but am very concerned.

    Anne

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It really ain't that tough
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Everything has omega-3

Everything has omega-3

Walking the supermarket aisles, you may have lately noticed that numerous new products are appearing sporting "omega-3s" on the label.

Some products simply contain alpha-linolenic acid, a tiny amount of which is converted to the biologically active omega-3s, EPA and DHA. Natural Ovens' Brainy Bagel, for instance, carries a claim of "620 omega-3."



I find this confusing and misleading, since people will often interpret such a claim to mean that it contains 620 of EPA and DHA, similar to two capsules of standard fish oil (1000 mg capsules). Of course, it does NOT. I find this especially troublesome when people will actually stop or reduce their fish oil, since they've been misled into thinking that products like this bread contain active omega-3 fatty acids that yield all the benefits of the "real stuff."


Other products actually contain the omega-3, DHA, though usually in small quantities. Breyer's Smart with DHA is an example, with 32 mg DHA per container.


I find products with actual DHA (from algae) a more credible claim. However, the Center for Science in the Public Interest (CSPI) has looked at the actual contents of DHA in some of these products and found some discrepancies, including amounts of DHA less than the labeled amount and claims of omega-3 wihtout specifying DHA vs. linolenic acid. (It's probably linolenic acid, if it's not specified.)

All in all, the addition of DHA to food products is a nice way to boost your intake of this healthy omega-3. However, keep in mind that these are processed, often highly processed, foods and you will likely pay a premium for the little boost. For now, stick to fish oil, the real thing.

For a brief summary of the CSPI report and a link to the Nutrition Action Newsletter, see Omega-3 Madness: Fish Oil or Snake Oil.

Comments (5) -

  • ethyl d

    11/8/2007 5:38:00 PM |

    I get really annoyed sometimes when grocery shopping by all the food manufacturers trying to manipulate us into buying their product by trumpeting whatever health angle they can get away with. "Only 100 calories!" "Good source of fiber!" "Low-fat!" Only 1g carb per serving!" "25% less sugar!" They sniff the air for whatever the latest health trend is and see how they can get their product modified a little while still remaining junk to cash in on the trend. They don't care about our health, they just want our money.

  • Michael

    11/8/2007 7:00:00 PM |

    There is one thing I am unsure about regarding all of the 'omega-3' products -- is it even healthy for men to use omega-3 products derived from non-fish (flax)? ALA has been shown to raise the risk of prostate cancer, although some studies also show other aspects of flax decreases the risk (making it all nice and confusing). I've also read, that for some people, who can't convert ALA to omega very well in their bodies,  flax can also raise inflammation levels.

    Should men even bother taking flax or products with  flax omega, at all? My own cardiologist pushes flax on me, oddly enough, even though I guzzle down plenty of fish oil. When I mention possible problems from flax, she basically drops the subject, leaving me in the dark as to why she suggested it in the first place.

  • Cindy Moore

    11/9/2007 4:21:00 AM |

    I saw a commercial for baby food with added DHA being marketed at helping your baby's brain development.

  • Carl

    11/10/2007 9:02:00 PM |

    I found this little article to contain very useful advice.  

    How to Eat - in Seven Words

    "Eat food," said Michael Pollan. "Not too much. Mostly plants."

    Seven words - short ones, no less, totaling eight syllables. Easy to spell, translate, or jot on a sticky note. But really, is that all that needs to be said?

    Pollan - a journalism professor at the University of California at Berkeley and author of the bestselling book The Omnivore's Dilemma - admits that boiling down advice on how human beings should eat to a mere seven words is dicey. A great deal, for example, depends on how one defines "food."

    But in a rousing presentation to a packed room of health professionals at the Fourth Annual Nutrition and Science Conference in San Diego, Calif., on May 2, 2007, Pollan argued that Americans have gone astray when it comes to thinking about food. While other cultures define food in terms of pleasure, sociability, religion or history, Americans are uniquely mesmerized by its scientific aspect.

    We are followers, Pollan said, of "nutritionism."

    "It is an ideology, a way of organizing experience," he said. "Like other 'isms' it rests on a simple set of assumptions, though we don't realize it." The connection between food, science, and health is "a real linkage," he said, "but it has overwhelmed all of the other linkages in our culture."

    Only in America, Pollan said, do people care more about food components - cholesterol, saturated fat, omega 3 oils, fiber and so on - than the foods themselves. And only in America can a low-fat craze grip the country, as it did from 1977 until 2002, to be displaced within a few months by a low-carb craze.

    The problem with nutritionism, Pollan said, is that it gives processed foods a huge advantage over whole foods. "A banana or potato cannot significantly change its structure. But any processed food can be changed overnight to correspond with food fads. You can even rejigger bread along Atkins lines." So the "loudest foods in the market" he said, are processed foods, touting their nutritional virtues via a $42 billion marketing industry, while "these poor whole foods just sit there silently."

    Thus, the irony: Americans are "a people obsessed with eating healthily, yet they are nonetheless very unhealthy."

    Nutrition science has value, Pollan said, but unbridled "nutritionism," pushed by processed food marketers has simply left people confused. In an attempt to simplify food, he came up with his seven-word, three-sentence manifesto, though he concedes that each sentence needs amplification:

    Eat food. The key term here, of course, is "food." We need to make hard distinctions between real food and "food-like products," Pollan said. Some guidelines:

    Don't eat food with more than five ingredients, or with ingredients you can't pronounce, or that contain high-fructose corn syrup (which serves as a 'marker' indicating that the food is highly processed).

    Eat only food that you have cooked, or could cook.

    Eat only food that your great, great grandmother would recognize as food.

    Not too much. The chief harm of nutritionism, Pollan said, is that processed food companies seize on "good nutrients" and "push us to eat more of them." The result is a tendency for Americans to eat more generally, which is one reason why we are consuming 300 calories more daily than in 1985. In the mass of verbiage surrounding food in America, plain overeating is "the elephant in the room." Pollan's advice to reverse the trend:

    Don't eat alone.

    Don't eat in front of the TV.

    Don't eat seconds.

    Perhaps most importantly, pay more and eat less. "I believe that the better quality food you eat, the less you need to feel satisfied."

    Mostly plants. "It's not that meat will kill you," he said. "I eat meat. Small amounts of meat have much to recommend them in terms of vitamins, minerals and taste. Most traditional diets - whether Mediterranean, Asian, Indian or Mexican, use meat sparingly, as a flavoring. I think that's an important lesson."

    By Brad Lemley
    DrWeil.com News

    http://www.drweil.com/drw/u/id/ART02840

  • Dr. Davis

    11/10/2007 11:20:00 PM |

    For anyone who has not read Michael Pollen's book, I would strongly urge you to read this logical and entertaining discussion that attempts to re-introduce rational thinking back into diet.

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