Petition to the National Institutes of Health

A petition to the National Institutes of Health (NIH) is being circulated in response to the mis-statement made in an NIH-sponsored study, ACCORD.

The ACCORD Trial included over 10,000 type II diabetics and compared an intensive, multiple-medication group to achieve a target HbA1c of <6.0%, with a less intensively treated group with a target HbA1c of 7-7.9%. (HBA1c is a long-term measure of glucose, averaging approximately the last 3 months glucose levels.) To the lead investigators' surprise, the intensively treated group experienced more death and heart attack than the less intensive group. The conclusion suggested that intensive management of diabetes may not be a desirable endpoint and may result in greater risk for adverse events.

The petitioners argue that the problem was not with intensive glucose control per se, but the use of multiple side-effect-generating medications. Unfortunately, the ACCORD conclusions give the impression that loose control over blood sugar may be desirable.

The petition originates from the Nutrition and Metabolism Society, a non-profit organization seeking to promote carbohydrate restriction.


The petition reads:

National Institute of Health re: the ACCORD Diabetes Study: "Intensively targeting blood sugar to near-normal levels ... increases risk of death. "

This statement is untrue. This study lowered blood glucose levels only by aggressive drug treatment.

Preventative measures and proven non-drug treatments are being ignored by the NIH, ADA and many other governing agencies.

There is abundant scientific evidence proving a carbohydrate restricted diet can be as effective as drugs in lowering blood glucose levels safely. Many times diet is more effective than medication in controlling diabetes - all without side effects or increased risk of death.

I ask that the NIH publicly retract the above statement. It is misleading the public.

I also request that the NIH acknowledge the existing science and fund more research by the experts who have experience with carbohydrate restriction as a means of treatment for diabetes.

For more info, or to help people with diabetes, please e-mail info@nmsociety.org .

Thank you.




I added my comment:

In my preventive cardiology practice, I have been employing strict carbohydrate restriction in both diabetics and non-diabetics. This results in dramatic improvement in lipids and lipoprotein abnormalities, substantial weight loss, and improved insulin sensitivity. This experience has been entirely different from the heart disease-causing and diabetes-causing low-fat diets that I used for years.

I have a substantial number of diabetics who have been to reduce their reliance on prescription medication for diabetes or even eliminate them. In my experience, the power of carbohydrate-restricted diets is profound.

However, better clinical data to further validate this approach is needed, particularly as diabetes and pre-diabetes is surging in prevalence. I ask that more funding to further explore and validate this research be made available if we are to have greater success on a broader basis.




If you are interested in adding your voice, you can also electronically sign the petition. It is optional, but you can also add your own comments regarding your own views or experiences.

Comments (2) -

  • Anonymous

    6/24/2008 12:42:00 PM |

    Looks like a wonderful petition to sign.  I didn't have anything to add, but placed my name onto it.

  • Anne

    6/24/2008 11:39:00 PM |

    I signed and commented. Thanks for letting us know about it.

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Is direct-to-consumer drug marketing a failure?

Is direct-to-consumer drug marketing a failure?

According to the poll just completed by 80 participants on The Heart Scan Blog, 50% of respondents said they were less likely to take a drug after viewing an advertisement for it. A whopping 3 (4%) said that they would be more likely to take the drug after viewing an advertisement.

I find that interesting. If half the people responding are less likely to become customers of a drug company, then how does the drug industry justify running around-the-clock, every-few-minute ads? Spending by the drug industry for direct-to-consumer (DTC) advertising has ballooned over the past few years, and is now well over $30 billion dollars per year.

Unfortunately, despite the views of the highly-educated, curious, think-for-yourself, health information-seeking sorts of people who read this blog, drug companies still come out on top by DTC advertising. Estimates vary, with a 2006 U.S. Government Accountability Office study reporting that, for every $1 DTC advertising, sales are increased by $2.20. A 2000 Harvard study showed a higher return of $4.40 for every advertising dollar spent.

I'm sure the drug companies themselves have a very tight accounting handle on their own set of figures. We may not be terribly fond of these people and their often suspect tactics, but they're not stupid. They are certainly not stupid when it comes to making money.

Interestingly, 80% of the funds spent on DTC advertising focus on the 20 or so most popular drugs, all of which are used for treatment of chronic conditions like high cholesterol and high blood pressure, markets that are large and long-term. It pays very little to advertise drugs that may serve small markets for a short period. The implicit message is that this is not at all about informing the public. It is about advertising to grow revenues and profits--pure and simple.

It makes me wonder what the results of our poll would have been had we conducted it in 2000 before many people hadn't yet been brought to the brink of vomiting from the endless onslaught of commercial after commercial, complete with smarmy spokespeople (a la Lipitor's Dr. Robert Jarvik). What will it show in two years? Will the broader public join the more informed people who read this blog and become increasingly inured to the hard sell tactics?

For further discussion of this topic, click here for a reprint of an August, 2007 New England Journal of Medicine study, A Decade of Direct-to-Consumer Advertising of Prescription Drugs provides background, along with commentary on the impact of DTC drug marketing since the FDA allowed it 10 years ago. (Because it is a study and not an editorial, the editors fall short of making any recommendations for improvement or calling for a moratorium.)


Copyright 2008 William Davis, MD

Comments (4) -

  • shreela

    4/23/2008 9:22:00 PM |

    I usually try to avoid taking a drug that hasn't been on the market for 5 years. One exception was when my knee doctor HIGHLY recommended Celebrex. It worked great at first, but the effectiveness wore off after a while, so I stopped taking it, and just took iced my knee when it swelled, and took ibuprofen if the ice wasn't enough. I also discovered later that biking brought down the swelling.

    Looking back on that, although I'm glad he gave me Celebrex instead of Vioxx (shudders), I'm glad I only took the Celebrex for a little while. Even though their commercial brag that they're the only prescription anti-inflammatory that hasn't been taken off the market, I recall reading about some severe side-effects I'd rather not have.

    If there's a natural way to decrease any ailment, I'd much rather try that, instead of taking a new drug, as long as there's studies that back up the natural treatment/diet. That's why I'm so grateful for your blog, and others like it from licensed health professionals; you and the others provide balance between the old school AMA way, and the 'alternative' methods that sometimes are a bit out there.

  • Anonymous

    4/24/2008 10:31:00 AM |

    It's all about supply and demand really. Make people believe they need it and they will want it. Marketing trumps truth a lot fortunately.

    But then there's those of us who realise that if a company's trying too hard to push something, they're trying to sell us off yogurt with a fragrance in it.

  • ethyl d

    4/24/2008 4:48:00 PM |

    Most Americans are not "highly-educated, curious, think-for-yourself, health information-seeking sorts of people," and many of them prefer taking a pill to control a health condition rather than changing what they eat and how they live, so the drug ads probably are influential. I also suspect that the bombardment of all those ads makes people more likely to worry about having or someday getting the diseases the drugs supposedly help with, and instilling the belief that prescription drugs are the best or even the only way to alleviate or cure the condition. "Don't worry, American public, if you get sick, we've got a pill to make you all better."

  • Anne

    4/26/2008 1:17:00 PM |

    I probably would have answered "more likely" 6 years ago before I got on the internet and met some very smart people. It was with their help I discovered that lifestyle changes, not more prescription medication, would do more to optimize my health. This is an ongoing journey. I am still learning.

    Sadly, I have found most people I meet are more interested in the newest drug for their symptoms than in changing lifestyle.

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