What's the best lipoprotein test?

This is a frequent question from Track Your Plaque Members and others interested in improving their heart disease prevention program beyond that of simple-minded cholesterol testing.

I obtain lipoprotein testing every day on patients. I can tell you with the confidence of having done thousands of these tests that plain, old-fashioned cholesterol testing is like relying on riding a scooter to work compared to an 8-cylinder modern automobile. The scooter might get you there, but any rain, snow, or long distance to travel and you can just forget it.

All too often, lipoprotein testing uncovers abnormalities that standard cholesterol testing simply fails to uncover.

So, among the various lipoprotein tests available, which is best?


There are three commercial tests available today:

1) Gel electropheresis (GGE)--often known by its "brand" name as the Berkeley lipoprotein profile, after Berkeley HeartLabs. GGE uses a gel with an electric field applied to cause lipoproteins to migrate, based on particle size and charge.

2) Vertical auto-profile (VAP)--a form of centrifugation, or high-speed spinning of blood plasma to separate lipoprotein particles.

3) Nuclear magnetic resonance (NMR)--the idea of putting plasma in an NMR (also known as MRI) device to characterize blood proteins.

All three tests do an excellent job. All are competitively priced. All have validating data--lots of it--to justify their broad use (though health insurers, in their vast wisdom, would still have you believe that the tests are "experimental").

But is one better?

Having done many of all three (though least of VAP), I am partial to Liposcience's NMR. (By the way, I receive no fees from Liposcience to use their test, nor to promote it in any way.)

I believe NMR is superior in a few ways:

1) I believe that the LDL particle number is the best way to truly quantify LDL, better than apoprotein B and "direct" LDL.

2) It provides what I believe to be more accurate small LDL measures.

3) It provides intermediate-density lipoprotein (IDL), a post-prandial, or after-eating, measure not available on the other two.

Perhaps I'm biased because I use the NMR most frequently. But I've used it because I felt it yielded superior, more clinically believable, data.

In truth, all three laboratories do an excellent job and you'd be served fine by obtaining any of the three. But my heart goes to NMR.

Comments (5) -

  • Anonymous

    5/30/2007 3:41:00 AM |

    Thank you for clarifying which test to use.  

    I personally find this information very helpful.

    My previous testing was done at Berkeley.

    How often do you suggest retesting be done?  Yearly or ??

    Thank you.

    Marilyn

  • Dr. Davis

    5/30/2007 11:30:00 AM |

    Marilyn--
    In the Track Your Plaque program, we advocate lipoprotein testing at the beginning to diagnose the full extent of causes of coronary plaque, and then again when correction is believed to have been achieved. Standard lipids are used in between to assess response. Of course, this is just one way we've used that we've become comfortable with.

  • Anonymous

    1/24/2009 12:51:00 AM |

    The VAP does provide IDL on their profile.

    What sort of external validation does NMR have on their methods?

  • Charlotte jess

    9/27/2010 12:35:23 PM |

    Randox provide a kit which tests for the full lipid profile - a group of tests comprising triglycerides, total cholesterol, HDL and LDL cholesterol. The lipid profile is used, together with other risk factors, to assess a person's risk of cardiovascular disease (CVD).

    It is very important to get the balance between the protective HDL and the destructive LDL right in order to reduce the risk of CVD. This can be achieved either through dietary and lifestyle changes or treatment with cholesterol reducing drugs called statins.

    All Randox cholesterol tests, including small LDL, are direct enzymatic clearance tests, and as such are highly accurate even in lipaemic samples.

    For more information click here http://www.randox.com/lipid%20profile.php

  • buy jeans

    11/3/2010 2:56:03 PM |

    Having done many of all three (though least of VAP), I am partial to Liposcience's NMR. (By the way, I receive no fees from Liposcience to use their test, nor to promote it in any way.)

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Mr. Salazar: Check your Lp(a)

Mr. Salazar: Check your Lp(a)

Marathon star Alberto Salazar was just released from the hospital following a heart attack and a heart catheterization that led to a stent. The MSNBC version of the report can be viewed at http://www.msnbc.msn.com/id/19653682/.

At 48 years old and holder of several American records for marathon times, Salazar's story is eerily reminiscent of Jim Fixx, who died at age 52 after writing a bestselling book, The Complete Book of Running. Thankfully, Salazar's story has a happier ending.

Fixx died at a time when prevention of heart disease was quite primitive. Lipoprotein analysis was not broadly available to the public, CT heart scans had not yet been invented. Even statin drugs were just a gleam in the pharmaceutical industry's eye.

But not so with Salazar. This Cuban-born marathoner experienced his heart attack at at a time when enormously useful steps can be taken to 1) document the extent of disease with a CT heart scan (the presence of a stent just means that one artery can't be "scored"), and 2) identify the causes of his disease.

I suspect that the fact that yet another marathoner in the limelight will once again prompt the (likely non-sensical) conversation about long-distance running and the increased risk of heart disease. Unfortunately, I fear that the real cause will be left unidentfied and untreated: Lipoprotein(a), or Lp(a).

It's almost certain that Fixx had Lp(a), given the fact that his dad had a heart attack at age 35. Running simply postponed the untreated inevitable.

I hope Mr. Salazar is surrounded by doctors who have his true interests in mind (not just procedural excitement) and ask the crucial question: Why?

The answer is almost certain to be Lp(a).

Comments (8) -

  • JT

    7/9/2007 11:29:00 AM |

    I know a group of guys that run marathons regularly.  If you asked them why they run, they will tell you there are two reasons; one to prevent heart disease and two to drink beer with out gaining weight.  Special emphasis will be placed on drinking beer.  I was reminded this week of how much the group enjoys their beer when the head of the group CCed me on a letter he wrote to Kroger grocery store pointing out that their Miller beer price is significantly higher priced than Wal-Mart, located just across the street.  If Kroger did not lower the price, well, they might just have to shop elsewhere.  

    I'm going to send them this blog and tell them they can stop running blind.  Today there are tests to determine if you have heart disease.  I'd suggest to them to drink red wine instead of beer, but that might be asking too much.

  • Dr. Davis

    7/9/2007 11:43:00 AM |

    That's great.

    Now we can only hope that their doc's know what to do next if any of them have Lp(a) or other "obscure" factors.

  • Mike

    7/9/2007 5:58:00 PM |

    When (what age) should one have a heart scan and Lp(a) test done if there are no symptoms? What would be the approximate cost to get the recommended testing done and evaluated?

  • traderfran2001

    7/10/2007 4:17:00 AM |

    I am curious as to why you focused on LPa as the likely cause. For example I am a regular runner and my LPa is in the low normal range. Is there something about running that makes LPa abnormalities more likely?

  • Dr. Davis

    7/10/2007 11:32:00 AM |

    Hi,
    I believe that the combination of Lp(a) and marathoners is no more likely than the general population, but it makes for media hype--the apparent contradictions of ultra-fitness and a disease generally associated with poor lifestyle. Lp(a) is, more often than not, the source of the contradiction.

  • John Townsend

    7/20/2007 11:08:00 PM |

    Do you have any advice on a Vitamin C/Lysine regimen? Apparently this combination was recommended (in high doses) by Linus Pauling years ago for cardiac health, particularly in controlling high levels of Lp(a). TIA

  • Dr. Davis

    7/21/2007 1:44:00 AM |

    John--

    I can only tell you that we've tried a number of times only to see no substantial effect.

    The concept has the basis in some real--and very interesting science--but the leap from a "test tube" observation to a "cure" for heart disease and cancer is, to say the least, a big one.

  • Dr. Davis

    7/28/2007 2:52:00 PM |

    Mike--Please see the extensive commentary on these issues on the Track Your Plaque website that this Blog accompanies. You will find an enormous amount of discussion, even in the non-Member, open content section.

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