Inner Circle Forums
Portions of the Undoctored Inner Circle Member Forum and its vast wealth of knowledge, are available only to our Members.
Becoming an Inner Circle Member will allow you to post topics, ask Dr. Davis questions, and view all replies.


Lancet study reveals breast cancer genes BRCA 1 and BRCA 2 do not cause breast cancer


Member Forum >> General Discussion >> Lancet study reveals breast cancer genes BRCA 1 and BRCA 2 do not cause breast cancer

Join Date: 11/15/2009
Posts Contributed: 7038
Total Likes: 214
Recommends Recd: 13
Ignores Issued: 0
Likes Recd: 0

HB  speaking. I thought this was interesting.

A powerful new Lancet study reveals that the so-called breast cancer susceptibility genes -- BRCA 1 and BRCA 2 -- do not, in fact, cause breast cancer.  Jolie’s prophylactic mastectomy, for instance, was for naught. 
Learn more

Germline BRCA mutation and outcome in young-onset breast cancer (POSH): a prospective cohort study

Prof Douglas G Altman, PhD
Prof Louise Jones, PhD
Prof D Gareth Evans, MD
Prof Paul Pharoah, PhD
Prof Douglas F Easton, PhD
Prof Andrew Hanby, BM
Prof Sunil Lakhani, MD
Prof Ros Eeles, PhD
Prof Fiona J Gilbert, MB


This study confirmed that patients diagnosed with invasive breast cancer aged 18–40 years have a high breast-cancer-specific mortality, and a high proportion are BRCA1 and BRCA2 mutation carriers. We found no clear evidence that either BRCA1 or BRCA2 germline mutations significantly affect overall survival with breast cancer after adjusting for known prognostic factors. Decisions about timing of risk-reducing surgery should take into account primary tumour prognosis and patient preference. BRCA mutation carriers presenting with triple-negative breast cancer might have an improved survival during the first few years after diagnosis compared with non-carriers, although immediate bilateral mastectomy did not account for this advantage. Finally, analysis of early outcome data from trials exploring BRCA-deficient tumour treatment in patients with triple-negative breast cancer should be interpreted with caution in view of the possible early survival advantage for BRCA mutation carriers.

 

 
 

http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(17)30891-4/fulltext?elsca1=tlpr

Tags:

Join Date: 5/20/2011
Posts Contributed: 1682
Total Likes: 551
Recommends Recd: 13
Ignores Issued: 0
Likes Recd: 1

HB
Can you explain above post as unsure as to what is being stated to us on the forum understanding you have an interest in this area 
Tags:

Join Date: 7/7/2014
Posts Contributed: 16154
Total Likes: 2420
Recommends Recd: 10
Ignores Issued: 0
Likes Recd: 1

Reply Content Hidden!

Post replies longer than 250 characters are restricted to Full Access Members (make certain you are logged-in!).

Sign Up Today!


Tags:

Join Date: 5/20/2011
Posts Contributed: 1682
Total Likes: 551
Recommends Recd: 13
Ignores Issued: 0
Likes Recd: 1

Bob - thanks as you linked the relevant article and who Jolie was and BCRA mutation 
Tags:

Join Date: 11/15/2009
Posts Contributed: 7038
Total Likes: 214
Recommends Recd: 13
Ignores Issued: 0
Likes Recd: 0
Posted: 1/14/2018 4:11:47 PM
Edited: 1/14/2018 4:12:27 PM (1)

KS. The post I made has nothing to do with the program. Bob explained it well.
Bob thanks for explaining it. HB
Tags:

Join Date: 5/20/2011
Posts Contributed: 1682
Total Likes: 551
Recommends Recd: 13
Ignores Issued: 0
Likes Recd: 1

Reply Content Hidden!

Post replies longer than 250 characters are restricted to Full Access Members (make certain you are logged-in!).

Sign Up Today!


Tags:

Join Date: 12/24/2007
Posts Contributed: 6648
Total Likes: 439
Recommends Recd: 16
Ignores Issued: 0
Likes Recd: 0

Reply Content Hidden!

Post replies longer than 250 characters are restricted to Full Access Members (make certain you are logged-in!).

Sign Up Today!


Tags:

Join Date: 11/15/2009
Posts Contributed: 7038
Total Likes: 214
Recommends Recd: 13
Ignores Issued: 0
Likes Recd: 0

Reply Content Hidden!

Post replies longer than 250 characters are restricted to Full Access Members (make certain you are logged-in!).

Sign Up Today!


Tags: APO E4,Bacterial infection

Dr. Davis

No Avatar
STAFF

Join Date: 12/20/2007
Posts Contributed: 10231
Total Likes: 1775
Recommends Recd: 15
Ignores Issued: 0
Likes Recd: 1

Reply Content Hidden!

Post replies longer than 250 characters are restricted to Full Access Members (make certain you are logged-in!).

Sign Up Today!


Tags:

Join Date: 11/15/2009
Posts Contributed: 7038
Total Likes: 214
Recommends Recd: 13
Ignores Issued: 0
Likes Recd: 0

Reply Content Hidden!

Post replies longer than 250 characters are restricted to Full Access Members (make certain you are logged-in!).

Sign Up Today!


Tags:

Join Date: 5/20/2011
Posts Contributed: 1682
Total Likes: 551
Recommends Recd: 13
Ignores Issued: 0
Likes Recd: 1
Posted: 1/15/2018 9:18:53 PM
Edited: 1/16/2018 5:53:54 AM (4)

Reply Content Hidden!

Post replies longer than 250 characters are restricted to Full Access Members (make certain you are logged-in!).

Sign Up Today!


Tags:

Join Date: 7/7/2014
Posts Contributed: 16154
Total Likes: 2420
Recommends Recd: 10
Ignores Issued: 0
Likes Recd: 0

Reply Content Hidden!

Post replies longer than 250 characters are restricted to Full Access Members (make certain you are logged-in!).

Sign Up Today!


Tags:

Join Date: 6/4/2017
Posts Contributed: 80
Total Likes: 9
Recommends Recd: 0
Ignores Issued: 0
Likes Recd: 0
Posted: 10/7/2018 4:50:11 PM
Edited: 10/7/2018 4:52:40 PM (1)

Reply Content Hidden!

Post replies longer than 250 characters are restricted to Full Access Members (make certain you are logged-in!).

Sign Up Today!


Tags: 23andMe,BRCA1,genetic testing