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Genetic variants on chromosome 4q25 are associated with atrial fibrillation


Member Forum >> Atrial Fibrillation Protocol >> Genetic variants on chromosome 4q25 are associated with atrial fibrillation

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Posted: 9/21/2017 5:37:42 PM
Edited: 9/21/2017 6:01:03 PM (3)

Two SNPs from chromosome 4q25, rs2200733 and rs10033464, were found to be associated with atrial fibrillation in a study of both European and Asian populations. The odds ratio associated with one or more copies of either risk allele was ~1.4x.[PMID 17603472]

[PMID 18931155] The results derived from a study of 78 Italians with atrial fibrillation (AF) and atrial flutter (AFL) agree with previously reported findings from the Icelandic study ([PMID 17603472]), which also found that the rs2200733(T) was associated with AF/AFL disease.

[PMID 18991354] In 1,661 Icelandic ischemic stroke samples and two large European replication sets combined, rs2200733 was associated with cardioembolic stroke (CES) (odds ratio 1.54, p = 8.05 x 10e-9). rs2200733 even showed association to ischemic stroke that was not classified as cardioembolic stroke.

[PMID 19141561OA-icon.png] rs2200733 and rs10033464 are strongly associated with AF in four cohorts of European descent.

The test is not expensive. Samples for DNA extraction are taken using buccal swabs (i.e. cheek swabs).
Of course,people who have had atrial fibrillation episodes have to focus on prevention and treatment.

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Posted: 9/22/2017 2:03:27 PM
Edited: 9/22/2017 2:12:40 PM (1)


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